ArticleThe EMBO journal2007
TBP paralogs accommodate metazoan- and vertebrate-specific developmental gene regulation.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Genomic and structural insights into TATA-Binding protein from cestodes.Transcription · 2026Article
- RNA-seq analysis of wild-type and mutated TBPL1 gene in breast cancer cells lines through CRISPR/Cas9 approach reveals novel molecular signatures.Scientific reports · 2025Article
- Functional implications of paralog genes in polyglutamine spinocerebellar ataxias.Human genetics · 2023Review
- Control of zygotic genome activation in Xenopus.Current topics in developmental biology · 2021Review
- TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage.Nature communications · 2020Article
- Activation of a T-box-Otx2-Gsc gene network independent of TBP and TBP-related factors.Development (Cambridge, England) · 2016Article
- TRF2: TRansForming the view of general transcription factors.Transcription · 2015Review
- A new paradigm for transcription factor TFIIB functionality.Scientific reports · 2014Article
- Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.Developmental cell · 2013Article
- Article
- Unique aspects of transcription regulation in male germ cells.Cold Spring Harbor perspectives in biology · 2011Review
- TBP-related factors: a paradigm of diversity in transcription initiation.Cell & bioscience · 2011Article
- Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation.Nature reviews. Genetics · 2010Review
- ChIP-chip designs to interrogate the genome of Xenopus embryos for transcription factor binding and epigenetic regulation.PloS one · 2010Article
- Promoting developmental transcription.Development (Cambridge, England) · 2010Review
- Shifting players and paradigms in cell-specific transcription.Molecular cell · 2009Review
- TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte.Genes & development · 2009Article
- TBP2 is a substitute for TBP in Xenopus oocyte transcription.BMC biology · 2009Article
- The RNA polymerase II core promoter - the gateway to transcription.Current opinion in cell biology · 2008Review
- TBP homologues in embryo transcription: who does what?EMBO reports · 2007Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
In addition to TATA-binding protein (TBP), a key factor for transcription initiation, the metazoan-specific TBP-like factor TLF/TRF2 and the vertebrate-specific factor TBP2/TRF3 are known to be required for transcription of specific subsets of genes. We have combined an antisense-knockdown approach with transcriptome profiling to determine the significance and biological role of TBP-independent transcription in early gastrula-stage Xenopus laevis embryos. Here, we report that, although each of the TBP family members is essential for embryonic development, relatively few genes depend on TBP in the embryo. Most of the transcripts that depend on TBP in the embryo are also expressed maternally and in adult stages, and show no functional specialization. In contrast, TLF is linked to preferential expression in embryos and shows functional specialization in catabolism. A requirement for TBP2 is linked to vertebrate-specific embryonic genes and ventral-specific expression. Therefore TBP paralogs are essential for the gene-regulatory repertoire that is directly linked to early embryogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.