ArticleThe Journal of physiology2007
Functional expression of ionotropic purinergic receptors on mouse taste bud cells.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Olfactory-gustatory cross-modal integration: mechanisms of aroma-induced sweetness enhancement, sensory evaluation methodologies, neuroimaging evidence and advances in influencing factors.Journal of advanced research · 2026Review
- Characteristics of A-type voltage-gated KCell and tissue research · 2024Article
- ATP-Induced Contractile Response of Esophageal Smooth Muscle in Mice.International journal of molecular sciences · 2024Article
- "Tripartite Synapses" in Taste Buds: A Role for Type I Glial-like Taste Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cell-type-independent expression of inwardly rectifying potassium currents in mouse fungiform taste bud cells.Physiological research · 2020Article
- Sensing Senses: Optical Biosensors to Study Gustation.Sensors (Basel, Switzerland) · 2020Review
- Whole transcriptome profiling of taste bud cells.Scientific reports · 2017Article
- Selective expression of muscarinic acetylcholine receptor subtype M3 by mouse type III taste bud cells.Pflugers Archiv : European journal of physiology · 2016Article
- Expression of calcium-activated chloride channels Ano1 and Ano2 in mouse taste cells.Pflugers Archiv : European journal of physiology · 2016Article
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- Mice Lacking Pannexin 1 Release ATP and Respond Normally to All Taste Qualities.Chemical senses · 2015Article
- Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice.The Journal of physiology · 2015Article
- Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute liver failure is modulated by P2Y2 receptor-mediated JNK activation.Journal of gastroenterology · 2014Article
- Synaptic communication and signal processing among sensory cells in taste buds.The Journal of physiology · 2014Article
- Nucleus of the solitary tract in the C57BL/6J mouse: Subnuclear parcellation, chorda tympani nerve projections, and brainstem connections.The Journal of comparative neurology · 2014Article
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- A taste for ATP: neurotransmission in taste buds.Frontiers in cellular neuroscience · 2013Review
- Two open states of P2X receptor channels.Frontiers in cellular neuroscience · 2013Review
- Role of the ectonucleotidase NTPDase2 in taste bud function.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Immunocytochemical analysis of P2X2 in rat circumvallate taste buds.BMC neuroscience · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotransmitter receptors on taste bud cells (TBCs) and taste nerve fibres are likely to contribute to taste transduction by mediating the interaction among TBCs and that between TBCs and taste nerve fibres. We investigated the functional expression of P2 receptor subtypes on TBCs of mouse fungiform papillae. Electrophysiological studies showed that 100 microm ATP applied to their basolateral membranes either depolarized or hyperpolarized a few cells per taste bud. Ca(2+) imaging showed that similarly applied 1 mum ATP, 30 microm BzATP (a P2X(7) agonist), or 1 microm 2MeSATP (a P2Y(1) and P2Y(11) agonist) increased intracellular Ca(2+) concentration, but 100 microm UTP (a P2Y(2) and P2Y(4) agonist) and alpha,beta-meATP (a P2X agonist except for P2X(2), P2X(4) and P2X(7)) did not. RT-PCR suggested the expression of P2X(2), P2X(4), P2X(7), P2Y(1), P2Y(13) and P2Y(14) among the seven P2X subtypes and seven P2Y subtypes examined. Immunohistostaining confirmed the expression of P2X(2). The exposure of the basolateral membranes to 3 mm ATP for 30 min caused the uptake of Lucifer Yellow CH in a few TBCs per taste bud. This was antagonized by 100 microm PPADS (a non-selective P2 blocker) and 1 microm KN-62 (a P2X(7) blocker). These results showed for the first time the functional expression of P2X(2) and P2X(7) on TBCs. The roles of P2 receptor subtypes in the taste transduction, and the renewal of TBCs, are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.