ArticleCurrent biology : CB2007
Drosophila BubR1 is essential for meiotic sister-chromatid cohesion and maintenance of synaptonemal complex.
Article in Current biology : CB, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- No transcription, no problem: Protein phosphorylation changes and the transition from oocyte to embryo.Current topics in developmental biology · 2025Review
- Distinct checkpoint and homolog biorientation pathways regulate meiosis I in Drosophila oocytes.PLoS genetics · 2025Article
- Distinct checkpoint and homolog biorientation pathways regulate meiosis I inbioRxiv : the preprint server for biology · 2024Article
- Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation inMolecular biology of the cell · 2024Article
- Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation inbioRxiv : the preprint server for biology · 2024Article
- Rice Cell Division Cycle 20s are required for faithful chromosome segregation and cytokinesis during meiosis.Plant physiology · 2022Article
- Sister centromere fusion during meiosis I depends on maintaining cohesins and destabilizing microtubule attachments.PLoS genetics · 2019Article
- Multiple Duties for Spindle Assembly Checkpoint Kinases in Meiosis.Frontiers in cell and developmental biology · 2017Review
- Kdm5/Lid Regulates Chromosome Architecture in Meiotic Prophase I Independently of Its Histone Demethylase Activity.PLoS genetics · 2016Article
- The spindle checkpoint and chromosome segregation in meiosis.The FEBS journal · 2015Review
- Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation.The EMBO journal · 2013Article
- akirin is required for diakinesis bivalent structure and synaptonemal complex disassembly at meiotic prophase I.Molecular biology of the cell · 2013Article
- A knockout screen for protein kinases required for the proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe.Cell cycle (Georgetown, Tex.) · 2013Article
- Strategies for outcrossing and genetic manipulation of Drosophila compound autosome stocks.G3 (Bethesda, Md.) · 2013Article
- Interplay between synaptonemal complex, homologous recombination, and centromeres during mammalian meiosis.PLoS genetics · 2012Article
- polo Is Identified as a Suppressor of bubR1 Nondisjunction in a Deficiency Screen of the Third Chromosome in Drosophila melanogaster.G3 (Bethesda, Md.) · 2011Article
- Article
- A spindle assembly checkpoint protein functions in prophase I arrest and prometaphase progression.Science (New York, N.Y.) · 2009Article
- Article
- Gradual reduction of BUBR1 protein levels results in premature sister-chromatid separation then in aneuploidy.Human genetics · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The partially conserved Mad3/BubR1 protein is required during mitosis for the spindle assembly checkpoint (SAC). In meiosis, depletion causes an accelerated transit through prophase I and missegregation of achiasmate chromosomes in yeast [1], whereas in mice, reduced dosage leads to severe chromosome missegregation [2]. These observations indicate a meiotic requirement for BubR1, but its mechanism of action remains unknown. We identified a viable bubR1 allele in Drosophila resulting from a point mutation in the kinase domain that retains mitotic SAC activity. In males, we demonstrate a dose-sensitive requirement for BubR1 in maintaining sister-chromatid cohesion at anaphase I, whereas the mutant BubR1 protein localizes correctly. In bubR1 mutant females, we find that both achiasmate and chiasmate chromosomes nondisjoin mostly equationally consistent with a defect in sister-chromatid cohesion at late anaphase I or meiosis II. Moreover, mutations in bubR1 cause a consistent increase in pericentric heterochromatin exchange frequency, and although the synaptonemal complex is set up properly during transit through the germarium, it is disassembled prematurely in prophase by stage 1. Our results demonstrate that BubR1 is essential to maintain sister-chromatid cohesion during meiotic progression in both sexes and for normal maintenance of SC in females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.