Evidence map›Paper›PMID 17701295›Full record

ArticleJournal of materials science. Materials in medicine2008

Fabrication of a PLGA-collagen peripheral nerve scaffold and investigation of its sustained release property in vitro.

Bin Liu, Shao-Xi Cai, Kai-Wang Ma, Zhi-Ling Xu, Xiao-Zhen Dai, Li Yang, Cai Lin, Xiao-Bing Fu, K L Paul Sung, Xiao-Kun Li

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. In vivo application of poly-3-hydroxyoctanoate as peripheral nerve graft.Journal of Zhejiang University. Science. B · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bin LiuCollege of Bioengineering, Chongqing University, Chongqing, 400044, P.R. China.
Shao-Xi Cai
Kai-Wang Ma
Zhi-Ling Xu
Xiao-Zhen Dai
Li Yang
Cai Lin
Xiao-Bing Fu
K L Paul Sung
Xiao-Kun Li

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study deals with the fabrication of a peripheral nerve scaffold prepared with poly (lactic acid-co-glycolic acid) [PLGA] and acellularized pigskin collagen micro particles and the investigation of its sustained release property in vitro. We took bovine serum albumin [BSA] as model drug to investigate the sustained-release property of the scaffold in vitro. The results showed the scaffold could release BSA steadily with a rate of 6.6 ng/d (r=0.994) or so. In a 1-month test period, the accumulative release ratio of BSA from the scaffold was up to 43%, and the shape of the scaffold was still originally well kept. In addition, the scaffold outcome non-immunogenicity, good cell adhesion and biodegradability. The results indicated a scaffold constructed by this technique would be a potential implanting support with prolonged sustained release function, such as for the use of nerve scaffold.

Indexed as

Peripheral NervesTissue ScaffoldsAnimalsBehavior, AnimalCell AdhesionCell-Free SystemCells, CulturedCollagenDelayed-Action PreparationsDrug CarriersExtracellular MatrixFemaleLactic AcidMaleMicrospheresNerve RegenerationCollagenDelayed-Action PreparationsDrug CarriersLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerSerum Albumin, Bovine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.