Trial reportSurgical endoscopy2008
Natural-orifice transgastric endoscopic peritoneoscopy in humans: Initial clinical trial.
Trial report in Surgical endoscopy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00427752 (Diagnostic Transluminal Endoscopic Peritoneoscopy), which is not on this map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diagnostic Transluminal Endoscopic Peritoneoscopy
Who cites it
62 citing papers in PubMed, 230 citations in OpenAlex.
- Diagnostic transgastric endoscopic peritoneoscopy: extension of the initial human trial for staging of pancreatic head masses.Surgical endoscopy · 2010Trial
- Natural orifice surgery: initial clinical experience.Surgical endoscopy · 2009Trial
- Transgastric endoscopic peritoneoscopy does not require decontamination of the stomach in humans.Surgical endoscopy · 2009Trial
- Transvaginal endoscopic surgery for tubal ectopic pregnancy.JSLS : Journal of the Society of Laparoendoscopic SurgeonsTrial
- Natural orifice transluminal endoscopic surgery: history and current development.Clinical endoscopy · 2026Review
- True natural orifice transluminal endoscopic surgery-transgastric cholecystectomy and beyond.Clinical endoscopy · 2025Review
- Natural orifice transluminal endoscopic surgery to the rescue: retrieval of an extraluminally migrated lumen-apposing metal stent.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024Article
- A new robotic-assisted flexible endoscope with single-hand control: endoscopic submucosal dissection in the ex vivo porcine stomach.Surgical endoscopy · 2018Article
- A New Era of Minimally Invasive Surgery: Progress and Development of Major Technical Innovations in General Surgery Over the Last Decade.Surgery journal (New York, N.Y.) · 2017Review
- Developments in flexible endoscopic surgery: a review.Clinical and experimental gastroenterology · 2015Review
- Stress response and well-being after open, laparoscopic, and NOTES transgastric uterine horn resection in a randomized porcine model.Surgical endoscopy · 2014Article
- "Down-to-Up" transanal NOTES Total mesorectal excision for rectal cancer: Preliminary series of 9 patients.Journal of minimal access surgery · 2014Article
- Natural orifice transluminal endoscopic surgery and upper gastrointestinal tract.Journal of gastric cancer · 2013Review
- Forward-viewing endoscopic ultrasound-guided NOTES interventions: a study on peritoneoscopic potential.World journal of gastroenterology · 2013Article
- NOTES for the management of an intra-abdominal abscess: transcolonic peritonoscopy and abscess drainage in a canine model.Canadian journal of surgery. Journal canadien de chirurgie · 2013Article
- Effect of transgastric peritoneal access on peritoneal innate cellular immunity: experimental study in swine.Surgical endoscopy · 2013Article
- Comparison of hemodynamic and inflammatory changes between transoral and transthoracic thoracoscopic surgery.PloS one · 2013Article
- Flexible versus rigid single-port peritoneoscopy: a randomized controlled trial in a live porcine model followed by initial experience in human cadavers.Surgical endoscopy · 2012Article
- Robot-assisted transvaginal peritoneoscopy using confocal endomicroscopy: a feasibility study in a porcine model.Surgical endoscopy · 2012Article
- Real-time computed tomography-based augmented reality for natural orifice transluminal endoscopic surgery navigation.The British journal of surgery · 2012Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNatural-orifice translumenal endoscopic surgery (NOTES) is a possible advancement for surgical interventions. We initiated a pilot study in humans to investigate feasibility and develop the techniques and technology necessary for NOTES. Reported herein is the first human clinical trial of NOTES, performing transoral transgastric diagnostic peritoneoscopy.
methodsPatients were scheduled to undergo diagnostic laparoscopic evaluation of a pancreatic mass. The findings of traditional laparoscopy were recorded by anatomical abdominal quadrant. A second surgeon, blinded to the laparoscopic findings, performed transgastric peritoneoscopy. Diagnostic findings between the two methods were compared and operative times and clinical course were recorded. Definitive care was based on findings at diagnostic laparoscopy.
resultsTen patients completed the protocol with an average age of 67.6 years. All patients underwent diagnostic laparoscopy followed by successful transgastric access and diagnostic endoscopic peritoneoscopy. The average time of diagnostic laparoscopy was 12.3 minutes compared to 24.8 minutes for the transgastric route. Transgastric abdominal exploration corroborated the decision to proceed to open exploration made during traditional laparoscopic exploration in 9 of 10 patients. Peritoneal or liver biopsies were obtained in four patients by traditional laparoscopy and in one patient by the transgastric access route. Findings were confirmed by laparotomy in nine patients. Eight patients underwent pancreaticoduodenectomy and two underwent palliative gastrojejunostomy and/or hepaticojejunostomy.
conclusionsTransgastric diagnostic peritoneoscopy is safe and feasible. This study demonstrates the initial steps of NOTES in humans, providing a potential platform for incisionless surgery. Technical issues, including instrumentation, visualization, intra-abdominal manipulation, and gastric closure need further development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.