ArticleVirchows Archiv : an international journal of pathology2007
Epithelial-mesenchymal transition (EMT) of renal tubular cells in canine glomerulonephritis.
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Pirfenidone inhibits TGF-β1-induced fibrosis via downregulation of Smad and ERK pathway in MDCK cells.Veterinary research communications · 2024Article
- A compared histopathological study on kidneys and eye bulbs in distinct clinical presentations of canine leishmaniasis by Leishmania infantum.Veterinary research communications · 2024Article
- An Overview of Epithelial-to-Mesenchymal Transition and Mesenchymal-to-Epithelial Transition in Canine Tumors: How Far Have We Come?Veterinary sciences · 2022Review
- Histological and immunohistochemical characterization of feline renal cell carcinoma: a case series.The Journal of veterinary medical science · 2016Article
- MicroRNA-590 is an EMT-suppressive microRNA involved in the TGFβ signaling pathway.Molecular medicine reports · 2015Article
- Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis.Frontiers in endocrinology · 2013Article
- Differential expression of proteoglycans in tissue remodeling and lymphangiogenesis after experimental renal transplantation in rats.PloS one · 2010Article
- New insights into epithelial-mesenchymal transition in kidney fibrosis.Journal of the American Society of Nephrology : JASN · 2010Review
- Dog as model for down-expression of E-cadherin and beta-catenin in tubular epithelial cells in renal fibrosis.Virchows Archiv : an international journal of pathology · 2008Article
- Decreased SMP30 Expression Is Related With EMT in the Kidneys of Two Siberian Tigers With CKD.In vivo (Athens, Greece)Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tubulo-interstitial fibrosis in dogs may result from primary injury to the interstitium or develop secondary to other renal diseases. As in human renal pathology, tubular epithelial cells (TEC) are believed to actively participate in the mechanisms of renal fibrosis. In this study, we examined the changes in the tubular epithelial component in two specific canine diseases. Immunohistochemistry showed the expression of the epithelial marker cytokeratin, the smooth muscle marker alpha-SMA, the mesenchymal marker vimentin and PCNA in 20 dogs with membranous glomerulonephritis and membrano-proliferative glomerulonephritis. Results showed that the loss of the epithelial marker in TEC was directly correlated to the grade of tubulo-interstitial disease present and independent of the type of glomerulonephritis. Varying degrees of vimentin positivity were detected in tubular epithelium in areas of inflammation, and low numbers of scattered alpha-SMA-positive cells were also observed. Immunohistochemistry showed that epithelial tubular cells lose their cytokeratin staining characteristics and transdifferentiate into cells exhibiting key mesenchymal immunophenotypic feature of vimentin-positive staining in both diseases investigated. The integrity of the tubular basement membrane is likely to be fundamental in maintaining the epithelial phenotype of TEC. Animal models provide opportunities for investigating the pathogenesis of renal fibrosis in humans.
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