ArticleJournal of biomolecular NMR2007
13C-detected NMR experiments for measuring chemical shifts and coupling constants in nucleic acid bases.
Article in Journal of biomolecular NMR, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Relaxation Optimized Heteronuclear Experiments for Extending the Size Limit of RNA Nuclear Magnetic Resonance.Journal of the American Chemical Society · 2025Article
- Single-Scan HeteronuclearThe journal of physical chemistry letters · 2024Article
- Review
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- More than Proton Detection-New Avenues for NMR Spectroscopy of RNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Review
- Direct evidence for (G)O6···HJournal of magnetic resonance (San Diego, Calif. : 1997) · 2019Article
- NovelAngewandte Chemie (International ed. in English) · 2019Article
- Evaluation ofJournal of biomolecular NMR · 2017Article
- Direct ¹³C-detected NMR experiments for mapping and characterization of hydrogen bonds in RNA.Journal of biomolecular NMR · 2016Article
- NMR structure analysis of uniformly 13C-labeled carbohydrates.Journal of biomolecular NMR · 2014Article
- Independent alignment of RNA for dynamic studies using residual dipolar couplings.Journal of biomolecular NMR · 2012Article
- Selective 13C labeling of nucleotides for large RNA NMR spectroscopy using an E. coli strain disabled in the TCA cycle.Journal of biomolecular NMR · 2010Article
- 13C-direct detected NMR experiments for the sequential J-based resonance assignment of RNA oligonucleotides.Journal of biomolecular NMR · 2010Article
- Site-specific labeling of nucleotides for making RNA for high resolution NMR studies using an E. coli strain disabled in the oxidative pentose phosphate pathway.Journal of biomolecular NMR · 2010Article
- High-resolution NMR structure of an RNA model system: the 14-mer cUUCGg tetraloop hairpin RNA.Nucleic acids research · 2010Article
- Relaxation-optimised Hartmann-Hahn transfer using a specifically Tailored MOCCA-XY16 mixing sequence for carbonyl-carbonyl correlation spectroscopy in 13C direct detection NMR experiments.Journal of biomolecular NMR · 2009Article
- Effect of local sugar and base geometry on 13C and 15N magnetic shielding anisotropy in DNA nucleosides.Journal of biomolecular NMR · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The paper presents a set of two-dimensional experiments that utilize direct (13)C detection to provide proton-carbon, carbon-carbon and carbon-nitrogen correlations in the bases of nucleic acids. The set includes a (13)C-detected proton-carbon correlation experiment for the measurement of (13)C-(13)C couplings, the CaCb experiment for correlating two quaternary carbons, the HCaCb experiment for the (13)C-(13)C correlations in cases where one of the carbons has a proton attached, the HCC-TOCSY experiment for correlating a proton with a network of coupled carbons, and a (13)C-detected (13)C-(15)N correlation experiment for detecting the nitrogen nuclei that cannot be detected via protons. The IPAP procedure is used for extracting the carbon-carbon couplings and/or carbon decoupling in the direct dimension, while the S(3)E procedure is preferred in the indirect dimension of the carbon-nitrogen experiment to obtain the value of the coupling constant. The experiments supply accurate values of (13)C and (15)N chemical shifts and carbon-carbon and carbon-nitrogen coupling constants. These values can help to reveal structural features of nucleic acids either directly or via induced changes when the sample is dissolved in oriented media.
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