ArticleCurrent genetics2007
The role of the glyoxylate cycle in the symbiotic fungus Tuber borchii: expression analysis and subcellular localization.
Article in Current genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- The Methylcitrate Cycle and Its Crosstalk with the Glyoxylate Cycle and Tricarboxylic Acid Cycle in Pathogenic Fungi.Molecules (Basel, Switzerland) · 2023Review
- Transcriptome Metabolic Characterization ofInternational journal of molecular sciences · 2023Article
- Peroxisomes and sexual development in fungi.Frontiers in physiology · 2013Review
- Proteins from Tuber magnatum Pico fruiting bodies naturally grown in different areas of Italy.Proteome science · 2013Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression profiles of isocitrate lyase (TbICL), malate synthase (TbMLS) and fructose-1,6-bisphosphatase (TbFBP) from the mycorrhizal ascomycete Tuber borchii were investigated by real-time RT-PCR in fruiting bodies at different stages of maturation. In addition, a time course experiment was set up to determine how the transcription profile of TbICL, TbMLS and TbFBP in axenic-grown mycelia is affected by different carbon sources. The transcript levels of the three genes in the fruiting bodies were all much higher than those measured in the vegetative stage. The investigation on axenic-grown mycelia revealed that the main positive regulator of TbICL and TbMLS gene expression is the availability of acetate and ethanol, while oleic acid is a too complex substrate for the limited degradative capacities of T. borchii. Immunolabelling on axenic-grown mycelia showed a co-localization of TbICL and the peroxisomal marker protein FOX2. This result demonstrated that in T. borchii ICL is compartmentalized in peroxisomes. The high induction of TbICL, TbMLS and TbFBP transcription and the translocation of lipids in fruiting bodies let us hypothesize that glyoxylate cycle and gluconeogenesis are key metabolic pathways in the recycling of existing cell material and the channelling towards the biosynthesis of new cell components during the maturation of fruiting bodies.
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