ArticleEuropean journal of clinical pharmacology2007
Persistence with antihypertensive treatments: results of a 3-year follow-up cohort study.
Article in European journal of clinical pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Updated report on comparative effectiveness of ACE inhibitors, ARBs, and direct renin inhibitors for patients with essential hypertension: much more data, little new information.Journal of general internal medicine · 2012Pooled it
- Single-pill vs free-equivalent combination therapies for hypertension: a meta-analysis of health care costs and adherence.Journal of clinical hypertension (Greenwich, Conn.) · 2011Pooled it
- Blood pressure reduction, persistence and costs in the evaluation of antihypertensive drug treatment--a review.Cardiovascular diabetology · 2009Pooled it
- Laboratory testing and antihypertensive medication adherence following initial treatment of incident, uncomplicated hypertension: A real-world data analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Starting Antihypertensive Drug Treatment With Combination Therapy: Controversies in Hypertension - Con Side of the Argument.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Effect of patient and treatment factors on persistence with antihypertensive treatment: A population-based study.PloS one · 2021Observational
- Hypertension and Drug Adherence in the Elderly.Frontiers in cardiovascular medicine · 2020Review
- Article
- Effectiveness of fixed-dose combination therapy in hypertension: systematic review and meta-analysis.Archives of medical science : AMS · 2018Review
- Age-Related Differences in Non-Persistence with Statin Treatment in Patients after a Transient Ischaemic Attack.Clinical drug investigation · 2017Article
- Comparison of therapy persistence for fixed versus free combination antihypertensives: a retrospective cohort study.BMJ open · 2016Article
- Persistence to antihypertensive drug classes: A cohort study using the Swedish Primary Care Cardiovascular Database (SPCCD).Medicine · 2016Observational
- How does prescribing for antihypertensive products stack up against guideline recommendations? An Australian population-based study (2006-2014).British journal of clinical pharmacology · 2016Article
- Persistence with Antihypertensive Medications in Uncomplicated Treatment-Naïve Patients: Effects of Initial Therapeutic Classes.Journal of Korean medical science · 2015Article
- Adherence to Disease Modifying Drugs among Patients with Multiple Sclerosis in Germany: A Retrospective Cohort Study.PloS one · 2015Article
- Adherence to Antihypertensive Therapy and Elevated Blood Pressure: Should We Consider the Use of Multiple Medications?PloS one · 2015Article
- Clinical impact of patient adherence to a fixed-dose combination of olmesartan, amlodipine and hydrochlorothiazide.Clinical drug investigation · 2014Observational
- Persistence of antihypertensive drug use in German primary care: a follow-up study based on pharmacy claims data.European journal of clinical pharmacology · 2014Article
- Patient compliance based on genetic medicine: a literature review.Journal of community genetics · 2014Article
- Persistence to antihypertensive drug treatment in Swedish primary healthcare.European journal of clinical pharmacology · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEffective treatment of hypertension requires continued prescribing of antihypertensive medications for many years. Persistence in prescribing habits, however, has been reported to be low. The study described herein - which is completely independent of pharmaceutical sponsors - was undertaken to evaluate persistence with antihypertensive treatment in Germany.
methodsA total of 13,763 newly diagnosed hypertensive patients were identified in the IMS Disease Analyzer database and observed for 3 years after their first antihypertensive prescription.
resultsThe median age of the study cohort was 65 years, and 56% were female. One in four patient received no more than three prescriptions within 3 years. Persistence was longest for patients whose initial prescription was for a free combination based on angiotensin converting enzyme inhibitors (median: 392.5 days), followed patients initially receiving a fixed combination, including angiotensin II receptor antagonists (208.5 days) and AIIRA monotherapy (168 days). Persistence was shortest with diuretics (57 days). Across all treatment groups, persistence after 3 years was 15.2%. Insurance status, sex and comorbidities were not found to impact persistence.
conclusionOur data indicate that persistence differs markedly among the drug classes (p < or = 0.001) but that even persistence of the best drug class is not sufficient to provide for an adequate blood pressure control in the population. The largest decline in persistence occurred in the first 3 months of treatment. More research is needed to elucidate the causes of this early drop in persistence and to develop effective means of improving the currently unsatisfactory situation.
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Registered trials
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