ReviewGene therapy2008
Gene therapy approaches for stem cell protection.
Review in Gene therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Intestinal Radiation Protection and Mitigation by Second-Generation ProbioticInternational journal of molecular sciences · 2022Article
- Space Radiation Protection Countermeasures in Microgravity and Planetary Exploration.Life (Basel, Switzerland) · 2021Review
- Article
- Protection against Radiotherapy-Induced Toxicity.Antioxidants (Basel, Switzerland) · 2016Review
- Hypoxia-preconditioned mesenchymal stem cells attenuate bleomycin-induced pulmonary fibrosis.Stem cell research & therapy · 2015Article
- Antioxidant Approaches to Management of Ionizing Irradiation Injury.Antioxidants (Basel, Switzerland) · 2015Article
- Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis.International journal of radiation biology · 2014Article
- New approaches to radiation protection.Frontiers in oncology · 2014Review
- Stem cell therapy: an exercise in patience and prudence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Normal tissue protection for improving radiotherapy: Where are the Gaps?Translational cancer research · 2012Article
- An acute negative bystander effect of γ-irradiated recipients on transplanted hematopoietic stem cells.Blood · 2012Article
- Ionizing radiation: the good, the bad, and the ugly.The Journal of investigative dermatology · 2012Review
- Strategies for discovery of small molecule radiation protectors and radiation mitigators.Frontiers in oncology · 2011Article
- SODa: an Mn/Fe superoxide dismutase prediction and design server.BMC bioinformatics · 2008Article
- The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation.In vivo (Athens, Greece)Article
- Intraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis.In vivo (Athens, Greece)Article
- The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Cytotoxic exposure of bone marrow and other non-hematopoietic organs containing self-renewing stem cell populations is associated with damage to the supportive microenvironment. Recent evidence indicates that radical oxygen species resulting from the initial oxidative stress persist for months after ionizing irradiation exposure of tissues including oral cavity, esophagus, lung and bone marrow. Antioxidant gene therapy using manganese superoxide dismutase plasmid liposomes has provided organ-specific radiation protection associated with delay or prevention of acute and late toxicity. Recent evidence has suggested that manganese superoxide dismutase transgene expression in cells of the organ microenvironment contributes significantly to the mechanism of protection. Incorporating this knowledge into designs of novel approaches for stem cell protection is addressed in the present review.
Indexed as
Identifiers
17700708What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.