Evidence map›Paper›PMID 17699831›Full record

ArticleClinical and vaccine immunology : CVI2007

Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

Sander Banus, Renske W B Bottema, Christine L E Siezen, Rob J Vandebriel, Johan Reimerink, Monique Mommers, Gerard H Koppelman, Barbara Hoebee, Carel Thijs, Dirkje S Postma and 2 more

Abstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sander BanusLaboratory of Vaccine-Preventable Diseases, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Renske W B Bottema
Christine L E Siezen
Rob J Vandebriel
Johan Reimerink
Monique Mommers
Gerard H Koppelman
Barbara Hoebee
Carel Thijs
Dirkje S Postma
Tjeerd G Kimman
Foekje F Stelma

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.

Indexed as

Polymorphism, Single NucleotideAnimalsCohort StudiesHumansImmunity, ActiveInfantMiceMice, Inbred C3HPertussis VaccineToll-Like Receptor 4Vaccines, AttenuatedPertussis VaccineTLR4 protein, humanToll-Like Receptor 4Vaccines, Attenuated

Identifiers

PMID17699831
PMCPMC2168111

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.