ArticleGenes & development2007
Independent and interdependent functions of LAF1 and HFR1 in phytochrome A signaling.
Article in Genes & development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- Genomic analysis uncovers functional variation in the C-terminus of anthocyanin-activating MYB transcription factors.Horticulture research · 2021Article
- Out of the Dark and Into the Light: A New View of Phytochrome Photobodies.Frontiers in plant science · 2021Review
- Specificity of MYB interactions relies on motifs in ordered and disordered contexts.Nucleic acids research · 2019Article
- TANDEM ZINC-FINGER/PLUS3 Is a Key Component of Phytochrome A Signaling.The Plant cell · 2018Article
- NUCLEAR FACTOR Y, Subunit C (NF-YC) Transcription Factors Are Positive Regulators of Photomorphogenesis in Arabidopsis thaliana.PLoS genetics · 2016Article
- Four Tomato FLOWERING LOCUS T-Like Proteins Act Antagonistically to Regulate Floral Initiation.Frontiers in plant science · 2015Article
- Both PHYTOCHROME RAPIDLY REGULATED1 (PAR1) and PAR2 promote seedling photomorphogenesis in multiple light signaling pathways.Plant physiology · 2014Article
- NITROGEN LIMITATION ADAPTATION recruits PHOSPHATE2 to target the phosphate transporter PT2 for degradation during the regulation of Arabidopsis phosphate homeostasis.The Plant cell · 2014Article
- Composition, roles, and regulation of cullin-based ubiquitin e3 ligases.The arabidopsis book · 2014Article
- Molecular interactions of BBX24 and BBX25 with HYH, HY5 HOMOLOG, to modulate Arabidopsis seedling development.Plant signaling & behavior · 2013Article
- Three transcription factors, HFR1, LAF1 and HY5, regulate largely independent signaling pathways downstream of phytochrome A.Plant & cell physiology · 2013Article
- The Arabidopsis B-BOX protein BBX25 interacts with HY5, negatively regulating BBX22 expression to suppress seedling photomorphogenesis.The Plant cell · 2013Article
- An evolutionarily conserved signaling mechanism mediates far-red light responses in land plants.The Plant cell · 2013Article
- The mediator complex subunit PFT1 interferes with COP1 and HY5 in the regulation of Arabidopsis light signaling.Plant physiology · 2012Article
- Functional interconnections of HY1 with MYC2 and HY5 in Arabidopsis seedling development.BMC plant biology · 2012Article
- Photobodies in light signaling.Plant physiology · 2012Review
- Ubiquitin ligase switch in plant photomorphogenesis: A hypothesis.Journal of theoretical biology · 2011Article
- Phytochrome signaling mechanisms.The arabidopsis book · 2011Article
- Arabidopsis transcription factor ELONGATED HYPOCOTYL5 plays a role in the feedback regulation of phytochrome A signaling.The Plant cell · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Several positive regulators of phytochrome A signaling--e.g., LAF1, HFR1, and HY5--operate downstream from the photoreceptor, but their relative sites of action in the transduction pathway are unknown. Here, we show that HFR1RNAi/laf1 or hfr1-201/LAF1RNAi generated by RNA interference (RNAi) has an additive phenotype under FR light compared with the single mutants, hfr1-201 or laf1. This result indicates that LAF1 and HFR1 function in largely independent pathways. LAF1, an R2R3-MYB factor, interacts with HFR1, a basic helix-loop-helix (bHLH) factor, and this interaction is abolished by the R97A mutation in the LAF1 R2R3 domain. Polyubiquitinations of LAF1 and HFR1 by the COP1 E3 ligase in vitro are inhibited by LAF1/HFR1 association. Consistent with this result, endogenous HFR1 is less stable in laf1 compared with wild type, and similarly, LAF1-3HA expressed from a transgene is also less stable in hfr1-201 than wild type. In transgenic plants, HFR1 levels are significantly elevated upon induced expression of LAF1 but not LAF1(R97A). Moreover, induced expression of LAF1 but not LAF1(R97A) delays post-translational HFR1 degradation in FR light. Constitutive coexpression of HFR1 and LAF1 but not HFR1 and LAF1 (R97A) confers FR hypersensitivity in double transgenic plants. Our results show that in addition to their independent functions in phyA signaling, LAF1 and HFR1 also cooperate post-translationally to stabilize each other through inhibition of ubiquitination by COP1, thereby enhancing phyA photoresponses.
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