ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Protein kinase C regulates local synthesis and secretion of a neuropeptide required for activity-dependent long-term synaptic plasticity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Comparison of the ionic currents modulated during activity-dependent and normal presynaptic facilitation.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- ACSS2-related autophagy has a dual impact on memory.Chinese neurosurgical journal · 2019Review
- Selective Erasure of Distinct Forms of Long-Term Synaptic Plasticity Underlying Different Forms of Memory in the Same Postsynaptic Neuron.Current biology : CB · 2017Article
- Cell-Specific PKM Isoforms Contribute to the Maintenance of Different Forms of Persistent Long-Term Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A PKM generated by calpain cleavage of a classical PKC is required for activity-dependent intermediate-term facilitation in the presynaptic sensory neuron of Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Persistent Associative Plasticity at an Identified Synapse Underlying Classical Conditioning Becomes Labile with Short-Term Homosynaptic Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Synaptic generation of an intracellular retrograde signal requires activation of the tyrosine kinase and mitogen-activated protein kinase signaling cascades in Aplysia.Neurobiology of learning and memory · 2015Article
- Activity-dependent inhibitory gating in molecular signaling cascades induces a novel form of intermediate-term synaptic facilitation in Aplysia californica.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Mechanistic basis and functional roles of long-term plasticity in auditory neurons induced by a brain-generated estrogen.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Mapping molecular memory: navigating the cellular pathways of learning.Cellular and molecular neurobiology · 2012Review
- Article
- Unique ionotropic receptors for D-aspartate are a target for serotonin-induced synaptic plasticity in Aplysia californica.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2012Article
- Computational design of enhanced learning protocols.Nature neuroscience · 2011Article
- Persistent long-term synaptic plasticity requires activation of a new signaling pathway by additional stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- PKG-mediated MAPK signaling is necessary for long-term operant memory in Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- PKA and PKC are required for long-term but not short-term in vivo operant memory in Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Aplysia cell adhesion molecule and a novel protein kinase C activity in the postsynaptic neuron are required for presynaptic growth and initial formation of specific synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Poly-(ADP-ribose) polymerase-1 is necessary for long-term facilitation in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Long-term facilitation (LTF) of sensory neuron synapses in Aplysia is produced by either nonassociative or associative stimuli. Nonassociative LTF can be produced by five spaced applications of serotonin (5-HT) and requires a phosphoinosotide 3-kinase (PI3K)-dependent and rapamycin-sensitive increase in the local synthesis of the sensory neuron neuropeptide sensorin and a protein kinase A (PKA)-dependent increase in the secretion of the newly synthesized sensorin. We report here that associative LTF produced by a single pairing of a brief tetanus with one application of 5-HT requires a rapid protein kinase C (PKC)-dependent and rapamycin-sensitive increase in local sensorin synthesis. This rapid increase in sensorin synthesis does not require PI3K activity or the presence of the sensory neuron cell body but does require the presence of the motor neuron. The secretion of newly synthesized sensorin by 2 h after stimulation requires both PKA and PKC activities to produce associative LTF because incubation with exogenous anti-sensorin antibody or the kinase inhibitors after tetanus plus 5-HT blocked LTF. The secreted sensorin leads to phosphorylation and translocation of p42/44 mitogen-activated protein kinase (MAPK) into the nuclei of the sensory neurons. Thus, different stimuli activating different signaling pathways converge by regulating the synthesis and release of a neuropeptide to produce long-term synaptic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.