ArticleProceedings of the National Academy of Sciences of the United States of America2007
Experimental validation of Haldane's hypothesis on the role of infection as an evolutionary force for Metazoans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
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- Translating eco-evolutionary biology into therapy to tackle antibiotic resistance.Nature reviews. Microbiology · 2023Review
- Alternative Non-Mammalian Animal and Cellular Methods for the Study of Host-Fungal Interactions.Journal of fungi (Basel, Switzerland) · 2023Review
- Metabolic properties, gene functions, and biosafety analysis reveal the action of three rhizospheric plant growth-promoting bacteria of Jujuncao (Pennisetum giganteum).Environmental science and pollution research international · 2022Article
- Mutational background influencesProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Metagenomics Analysis Reveals an Extraordinary Inner Bacterial Diversity in Anisakids (Nematoda: Anisakidae) L3 Larvae.Microorganisms · 2021Article
- Biological Control ofMicroorganisms · 2020Article
- The involvement of McpB chemoreceptor from Pseudomonas aeruginosa PAO1 in virulence.Scientific reports · 2019Article
- Respiratory analysis as a tool to detect physiological changes in Anisakis larvae subjected to stress.Parasitology research · 2019Article
- Interplay among Resistance Profiles, High-Risk Clones, and Virulence in the Caenorhabditis elegans Pseudomonas aeruginosa Infection Model.Antimicrobial agents and chemotherapy · 2017Article
- Evolution of Pseudomonas aeruginosa Antimicrobial Resistance and Fitness under Low and High Mutation Rates.Antimicrobial agents and chemotherapy · 2016Article
- Biosafety Test for Plant Growth-Promoting Bacteria: Proposed Environmental and Human Safety Index (EHSI) Protocol.Frontiers in microbiology · 2015Article
- Short-sighted evolution of bacterial opportunistic pathogens with an environmental origin.Frontiers in microbiology · 2014Article
- Article
- Caenorhabditis elegans-based model systems for antifungal drug discovery.Current pharmaceutical design · 2011Review
- Polymorphic mutation frequencies of clinical and environmental Stenotrophomonas maltophilia populations.Applied and environmental microbiology · 2010Article
- Making the right connections: biological networks in the light of evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2009Article
- The role of natural environments in the evolution of resistance traits in pathogenic bacteria.Proceedings. Biological sciences · 2009Review
- Antifungal drug discovery through the study of invertebrate model hosts.Current medicinal chemistry · 2009Review
- Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains.BMC microbiology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A common drawback in evolutionary science is the fact that the evolution of organisms occurs in geological timing, completely out of the time scale of laboratory experimental work. For this reason, some relevant hypotheses on evolution of Metazoans are based on correlations more than on experimental data obtained for testing the robustness of those hypotheses. In the current work, we implement an experimental methodology to analyze the role of infections as a driving force in the evolution of Metazoans (Haldane's hypothesis). To that goal, we have used simple models of virulence with short reproduction times, large populations, and that are easily testable in the laboratory. Using the bacteriovirus nematode Caenorhabditis elegans as a model organism under evolution and their infection by the environmental opportunistic bacterial pathogen Pseudomonas aeruginosa as the selective force, we have demonstrated that bacterial infection selects an evolved nematode lineage resistant to infection, with changes in its respiration and capability of consuming novel food resources. Using an experimental approach, we show that infection is a selective force in the evolution of Metazoans as proposed earlier by Haldane.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.