ArticleMolecular cancer research : MCR2007
Ataxia telangiectasia-mutated dependent DNA damage checkpoint functions regulate gene expression in human fibroblasts.
Article in Molecular cancer research : MCR, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Cerebellar glutamatergic system impacts spontaneous motor recovery by regulating Gria1 expression.NPJ Regenerative medicine · 2022Article
- Alerting the immune system to DNA damage: micronuclei as mediators.Essays in biochemistry · 2020Review
- Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders.Advances in neurobiology · 2017Review
- Development of a prediction model for radiosensitivity using the expression values of genes and long non-coding RNAs.Oncotarget · 2016Article
- Infection of a Single Cell Line with Distinct Strains of Human Cytomegalovirus Can Result in Large Variations in Virion Production and Facilitate Efficient Screening of Virus Protein Function.Journal of virology · 2015Article
- Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals.Physiological genomics · 2013Article
- A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines.Pigment cell & melanoma research · 2012Article
- Ionizing radiation induced signaling of DNA damage response molecules in RAW 264.7 and CD4⁺ T cells.Molecular and cellular biochemistry · 2012Article
- A flexible and qualitatively stable model for cell cycle dynamics including DNA damage effects.Gene regulation and systems biology · 2012Article
- Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM.Cell cycle (Georgetown, Tex.) · 2010Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
The relationships between profiles of global gene expression and DNA damage checkpoint functions were studied in cells from patients with ataxia telangiectasia (AT). Three telomerase-expressing AT fibroblast lines displayed the expected hypersensitivity to ionizing radiation (IR) and defects in DNA damage checkpoints. Profiles of global gene expression in AT cells were determined at 2, 6, and 24 h after treatment with 1.5-Gy IR or sham treatment and were compared with those previously recognized in normal human fibroblasts. Under basal conditions, 160 genes or expressed sequence tags were differentially expressed in AT and normal fibroblasts, and these were associated by gene ontology with insulin-like growth factor binding and regulation of cell growth. On DNA damage, 1,091 gene mRNAs were changed in at least two of the three AT cell lines. When compared with the 1,811 genes changed in normal human fibroblasts after the same treatment, 715 were found in both AT and normal fibroblasts, including most genes categorized by gene ontology into cell cycle, cell growth, and DNA damage response pathways. However, the IR-induced changes in these 715 genes in AT cells usually were delayed or attenuated in comparison with normal cells. The reduced change in DNA damage response genes and the attenuated repression of cell cycle-regulated genes may account for the defects in cell cycle checkpoint function in AT cells.
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