ArticleGut2007
Epidemiological trends of pre-malignant gastric lesions: a long-term nationwide study in the Netherlands.
Article in Gut, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 88 citations in OpenAlex.
- Optimizing endoscopic detection of precancerous gastric conditions: Single-center prospective study.Endoscopy international open · 2025Article
- Inflammation and Gastric Cancer.Diseases (Basel, Switzerland) · 2022Review
- Detection and Treatment ofGastroenterology research and practice · 2022Review
- Risk Factors Analysis and Prediction Model Establishment of Intestinal Metaplasia or Dysplasia in Patients With Chronic Atrophic Gastritis: A Multi-Center Retrospective Study.Frontiers in medicine · 2022Article
- The Single-Nucleotide Polymorphism of miR-27aEvidence-based complementary and alternative medicine : eCAM · 2022Article
- High-risk individuals for gastric cancer would be missed for surveillance without subtyping of intestinal metaplasia.Virchows Archiv : an international journal of pathology · 2021Article
- HDAC6/HNF4α loop mediated by miR-1 promotes bile acids-induced gastric intestinal metaplasia.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021Article
- Observational
- Current Perspectives in Atrophic Gastritis.Current gastroenterology reports · 2020Review
- Biopsy strategies for endoscopic screening of pre-malignant gastric lesions.Scientific reports · 2019Observational
- Gastric Cancer: an Evolving Disease.Current treatment options in gastroenterology · 2018Review
- Increased risk for metachronous gastric adenocarcinoma following gastric MALT lymphoma-A US population-based study.United European gastroenterology journal · 2017Article
- Article
- New advances in targeted gastric cancer treatment.World journal of gastroenterology · 2016Review
- Characteristics of gastric cancer in peptic ulcer patients with Helicobacter pylori infection.World journal of gastroenterology · 2015Article
- Gastroduodenal Changes Two Years After Eradication of Helicobacter pylori in a Population-Based Cohort.Gastroenterology research · 2015Article
- Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development.World journal of gastroenterology · 2014Review
- Expression of the matrix metalloproteases 2, 14, 24, and 25 and tissue inhibitor 3 as potential molecular markers in advanced human gastric cancer.Disease markers · 2014Article
- Ethnicity is a strong predictor for Helicobacter pylori infection in young women in a multi-ethnic European city.Journal of gastroenterology and hepatology · 2013Article
- Biomarkers predicting development of metachronous gastric cancer after endoscopic resection: an analysis of molecular pathology of Helicobacter pylori eradication.International journal of cancer · 2012Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pre-malignant gastric lesions atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia (DYS) have long been identified as principal risk factors for gastric cancer.
objectiveTo evaluate epidemiological time trends of pre-malignant gastric lesions in the Netherlands.
methodsPatients with a first diagnosis of AG, IM or DYS between 1991 and 2005 were identified in the Dutch nationwide histopathology registry. The number of new diagnoses per year were evaluated relative to the total number of patients with a first gastric biopsy. Time trends were evaluated with age-period-cohort models using logistic regression analysis.
resultsIn total, 23 278 patients were newly diagnosed with AG, 65 937 patients with IM, and 8517 patients with DYS. The incidence of AG declined similarly in men and women with 8.2% per year [95% CI 7.9% to 8.6%], and DYS with 8.1% per year [95% CI 7.5% to 8.6%]. The proportional number of new IM cases declined with 2.9% per year [95% CI 2.7% to 3.1%] in men and 2.4% [95% CI 2.2% to 2.6%] in women. With age-period-cohort models a cohort phenomenon was demonstrated for all categories of pre-malignant gastric lesions in men and in women with IM and DYS. Period phenomena with a larger decline in number of diagnoses after 1996 were also demonstrated for AG and IM.
conclusionsThe incidence of pre-malignant gastric lesions is declining. Period and cohort phenomena were demonstrated for diagnoses of AG and IM. These findings imply that a further decrease of at least 24% in the incidence of gastric cancer in the coming decade may be anticipated in Western countries without specific intervention.
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