ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2007
Interaction between lopinavir/ritonavir and warfarin.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir.Drug metabolism and disposition: the biological fate of chemicals · 2011Trial
- A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.Clinical pharmacology and therapeutics · 2010Trial
- Interactions of the protease inhibitor, ritonavir, with common anesthesia drugs.Paediatric anaesthesia · 2022Review
- Management of Comedication in Hospitalized COVID-19 Patients With Atrial Fibrillation.Hospital pharmacy · 2021Article
- Pharmacotherapeutic agents for the management of COVID-19 patients with preexisting cardiovascular disease.Expert opinion on pharmacotherapy · 2021Review
- Lopinavir-Ritonavir in SARS-CoV-2 Infection and Drug-Drug Interactions with Cardioactive Medications.Cardiovascular drugs and therapy · 2021Review
- Drug interactions: a review of the unseen danger of experimental COVID-19 therapies.The Journal of antimicrobial chemotherapy · 2020Review
- Prosthetic heart valves and the COVID-19 pandemic era: What should we be concerned about?Journal of cardiac surgery · 2020Article
- The challenge of HIV treatment in an era of polypharmacy.Journal of the International AIDS Society · 2020Review
- Managing drug interactions in HIV-infected adults with comorbid illness.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2015Review
- Influence of ORM1 polymorphisms on the maintenance stable warfarin dosage.European journal of clinical pharmacology · 2013Article
- Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir.Drug metabolism and disposition: the biological fate of chemicals · 2011Article
- Drug and dietary interactions of warfarin and novel oral anticoagulants: an update.Journal of thrombosis and thrombolysis · 2011Review
- HIV-Associated Venous Thromboembolism.Mediterranean journal of hematology and infectious diseases · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug interactions involving protease inhibitors are common. Protease inhibitors are well known inhibitors of the 3A4 isozyme of cytochrome P450. Select protease inhibitors, including co-formulated lopinavir/ritonavir, may induce glucuronidation or the activity of other CYP450 isozymes. We describe the case of a patient taking warfarin who experienced a significantly decreased international normalized ratio after the initiation of antiretroviral therapy that included lopinavir/ritonavir. We review the possible mechanisms of this interaction and the reported interactions between warfarin and other protease inhibitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.