Evidence map›Paper›PMID 17698630›Full record

ArticleAntimicrobial agents and chemotherapy2007

Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast.

Erica L Dahl, Philip J Rosenthal

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 3 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

183 citing papers in PubMed, 3 syntheses or guidelines pooled it, 335 citations in OpenAlex.

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123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Erica L DahlDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143-0811, USA.
Philip J Rosenthal
University of California, San Francisco · US

Funding

Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
Novel Tetracycyclines as Antimalarial DrugsR42AI051800 · NIAID · PARATEK PHARMACEUTICALS · PI DRAPER, MICHAEL P · 2004 to 2005
$2.6M
Development of Novel Tetracyclines as Antimalarial DrugsR43AI051800 · NIAID · PARATEK PHARMACEUTICALS · PI DRAPER, MICHAEL P · 2002 to 2002
$99k
NIAID NIH HHS R01 AI051800NIAID NIH HHS R42 AI051800NIAID NIH HHS R43 AI051800NIAID NIH HHS T32 AI060537
6 · The paper itself

Abstract

Several classes of antibiotics exert antimalarial activity. The mechanisms of action of antibiotics against malaria parasites have been unclear, and prior studies have led to conflicting results, in part because they studied antibiotics at suprapharmacological concentrations. We examined the antimalarial effects of azithromycin, ciprofloxacin, clindamycin, doxycycline, and rifampin against chloroquine-resistant (W2) and chloroquine-sensitive (3D7) Plasmodium falciparum strains. At clinically relevant concentrations, rifampin killed parasites quickly, preventing them from initiating cell division. In contrast, pharmacological concentrations of azithromycin, ciprofloxacin, clindamycin, and doxycycline were relatively inactive against parasites initially but exerted a delayed death effect, in which the progeny of treated parasites failed to complete erythrocytic development. The drugs that caused delayed death did not alter the distribution of apicoplasts into developing progeny. However, the apicoplasts inherited by the progeny of treated parasites were abnormal. The loss of apicoplast function became apparent as the progeny of antibiotic-treated parasites initiated cell division, with the failure of schizonts to fully mature or for erythrocyte rupture to take place. These findings explain the slow antimalarial action of multiple antibiotics.

Indexed as

AnimalsAnti-Bacterial AgentsAntimalarialsDrug ResistanceFlow CytometryGreen Fluorescent ProteinsPlasmodium falciparumProtein Synthesis InhibitorsTopoisomerase II InhibitorsAnti-Bacterial AgentsAntimalarialsGreen Fluorescent ProteinsProtein Synthesis InhibitorsTopoisomerase II Inhibitors

Identifiers

PMID17698630
PMCPMC2043295
OpenAlexW2007852671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.