ArticleAntimicrobial agents and chemotherapy2007
The antifungal polyketide ambruticin targets the HOG pathway.
Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A General Strategy for the Synthesis of Jerangolids Enabled by π-allyl Stille Coupling.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Genetic engineering of Sorangium cellulosum reveals hidden enzymology in myxobacterial natural product biosynthesis.Nature communications · 2025Article
- Total Synthesis of Jerangolid B via spOrganic letters · 2025Article
- The Corey-Seebach Reagent in the 21st Century: A Review.Molecules (Basel, Switzerland) · 2023Review
- Myxobacterial Outer Membrane β-1,6-Glucanase Induced the Cell Death of Fusarium oxysporum by Destroying the Cell Wall Integrity.Applied and environmental microbiology · 2023Article
- Current Landscape of Coccidioidomycosis.Journal of fungi (Basel, Switzerland) · 2022Review
- Enantioselective Total Synthesis of the Putative Biosynthetic Intermediate Ambruticin J.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- The Future of Antifungal Drug Therapy: Novel Compounds and Targets.Antimicrobial agents and chemotherapy · 2021Review
- Cytochrome P450 Monooxygenase CYP139 Family Involved in the Synthesis of Secondary Metabolites in 824 Mycobacterial Species.International journal of molecular sciences · 2019Article
- Uncertainty surrounding the mechanism and safety of the post-harvest fungicide fludioxonil.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2019Review
- Hog1p activation by marasmic acid through inhibition of the histidine kinase Sln1p.Pest management science · 2016Article
- Histidine kinases mediate differentiation, stress response, and pathogenicity in Magnaporthe oryzae.MicrobiologyOpen · 2014Article
- Deletion of the HAMP domains from the histidine kinase CaNik1p of Candida albicans or treatment with fungicides activates the MAP kinase Hog1p in S. cerevisiae transformants.BMC microbiology · 2013Article
- The Neurospora crassa OS MAPK pathway-activated transcription factor ASL-1 contributes to circadian rhythms in pathway responsive clock-controlled genes.Fungal genetics and biology : FG & B · 2012Article
- The group III two-component histidine kinase of filamentous fungi is involved in the fungicidal activity of the bacterial polyketide ambruticin.Applied and environmental microbiology · 2009Article
- Involvement of putative response regulator genes of the rice blast fungus Magnaporthe oryzae in osmotic stress response, fungicide action, and pathogenicity.Current genetics · 2008Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of action has not yet been elucidated. Here we present evidence that ambruticin exerts its effect by targeting HOG, the osmotic stress control pathway, through Hik1, a group III histidine kinase.
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