ArticleThe Journal of cell biology2007
Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Forty-one degrees celsius enhances proliferation of chicken muscle satellite cells via mechanistic target of rapamycin activation and mitochondrial metabolism.Poultry science · 2025Article
- MyoD is required for the differentiation of Myo/Nog cell progenitors of myofibroblasts in explants of human lens tissue.Frontiers in ophthalmology · 2025Article
- Review
- Myo/Nog Cells Give Rise to Myofibroblasts During Epiretinal Membrane Formation in a Mouse Model of Proliferative Vitreoretinopathy.Investigative ophthalmology & visual science · 2023Article
- Article
- Myo/Nog cells are nonprofessional phagocytes.PloS one · 2020Article
- Article
- Myo/Nog cells are present in the ciliary processes, on the zonule of Zinn and posterior capsule of the lens following cataract surgery.Experimental eye research · 2018Article
- Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Immediate and long-term transcriptional response of hind muscle tissue to transient variation of incubation temperature in broilers.BMC genomics · 2016Article
- Ancestral Myf5 gene activity in periocular connective tissue identifies a subset of fibro/adipogenic progenitors but does not connote a myogenic origin.Developmental biology · 2014Article
- Myo/Nog cells: targets for preventing the accumulation of skeletal muscle-like cells in the human lens.PloS one · 2014Article
- Myo/Nog cell regulation of bone morphogenetic protein signaling in the blastocyst is essential for normal morphogenesis and striated muscle lineage specification.Developmental biology · 2011Article
- Noggin producing, MyoD-positive cells are crucial for eye development.Developmental biology · 2009Article
- Progenitors of skeletal muscle satellite cells express the muscle determination gene, MyoD.Developmental biology · 2009Article
- Tracking and ablating subpopulations of epiblast cells in the chick embryo.Biological procedures online · 2008Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The epiblast of the chick embryo contains cells that express MyoD mRNA but not MyoD protein. We investigated whether MyoD-positive (MyoDpos) epiblast cells are stably committed to the skeletal muscle lineage or whether their fate can be altered in different environments. A small number of MyoDpos epiblast cells were tracked into the heart and nervous system. In these locations, they expressed MyoD mRNA and some synthesized MyoD protein. No MyoDpos epiblast cells differentiated into cardiac muscle or neurons. Similar results were obtained when MyoDpos cells were isolated from the epiblast and microinjected into the precardiac mesoderm or neural plate. In contrast, epiblast cells lacking MyoD differentiated according to their environment. These results demonstrate that the epiblast contains both multipotent cells and a subpopulation of cells that are stably committed to the skeletal muscle lineage before the onset of gastrulation. Stable programming in the epiblast may ensure that MyoDpos cells express similar signaling molecules in a variety of environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.