ArticleInfection and immunity2007
CD4 T-cell epitopes associated with protective immunity induced following vaccination of mice with an ehrlichial variable outer membrane protein.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
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- Vaccine development: obligate intracellular bacteria new tools, old pathogens: the current state of vaccines against obligate intracellular bacteria.Frontiers in cellular and infection microbiology · 2024Review
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- Vaccination against Bacterial Infections: Challenges, Progress, and New Approaches with a Focus on Intracellular Bacteria.Vaccines · 2022Review
- Type I interferons promote severe disease in a mouse model of lethal ehrlichiosis.Infection and immunity · 2014Article
- Molecular characterization and identification of Th1 epitopes of a Schistosoma japonicum protein similar to prosaposin.Parasitology research · 2014Article
- Recombinant Ehrlichia P29 protein induces a protective immune response in a mouse model of ehrlichiosis.Vaccine · 2013Article
- T cell-dependent IgM memory B cells generated during bacterial infection are required for IgG responses to antigen challenge.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Immunization with Ehrlichia P28 outer membrane proteins confers protection in a mouse model of ehrlichiosis.Clinical and vaccine immunology : CVI · 2011Article
- IgM production by bone marrow plasmablasts contributes to long-term protection against intracellular bacterial infection.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
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- Progress and obstacles in vaccine development for the ehrlichioses.Expert review of vaccines · 2010Review
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- Impaired germinal center responses and suppression of local IgG production during intracellular bacterial infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Antigen display, T-cell activation, and immune evasion during acute and chronic ehrlichiosis.Infection and immunity · 2009Article
- Diversity of Ehrlichia ruminantium major antigenic protein 1-2 in field isolates and infected sheep.Infection and immunity · 2009Article
- Ixodes ovatus Ehrlichia exhibits unique ultrastructural characteristics in mammalian endothelial and tick-derived cells.Annals of the New York Academy of Sciences · 2009Article
- Defining the immune response to Ehrlichia species using murine models.Veterinary parasitology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The ehrlichiae express variable outer membrane proteins (OMPs) that play important roles in both pathogenesis and host defense. Previous studies revealed that OMPs are immunodominant B-cell antigens and that passive transfer of anti-OMP antibodies can protect SCID mice from fatal ehrlichial infection. In this study, we used a model of fatal monocytotropic ehrlichiosis caused by Ehrlichia bacteria from Ixodes ovatus (IOE) to determine whether OMP immunization could generate protective immunity in immunocompetent mice. Immunization of C57BL/6 mice with a purified recombinant OMP expressed by IOE omp19 generated protection from fatal IOE infection and elicited robust humoral and CD4 T-cell responses. To identify CD4 T-cell epitopes within OMPs, we performed enzyme-linked immunospot analyses for gamma interferon (IFN-gamma) production using a panel of overlapping 16-mer peptides from IOE OMP-19. Five immunoreactive peptides comprising residues 30 to 45, 77 to 92, 107 to 122, 197 to 212, and 247 to 264 were identified; the strongest response was generated against OMP-19(107-122). Most of the peptides are conserved between E. muris and E. chaffeensis OMP-19, and they elicited IFN-gamma production in CD4 T cells from E. muris-infected mice, indicating that T-cell epitope cross-reactivity likely contributes to heterologous immunity. Accordingly, CD4 T-cell responses to both OMP-19 and OMP-19(107-122) were of greater magnitude following high-dose IOE challenge of mice that had been immunized by prior infection with E. muris. Our studies cumulatively identify B- and T-cell epitopes that are associated with protective homologous and heterologous immunity during ehrlichial infection.
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