ArticleInfection and immunity2007
The O antigen enables Bordetella parapertussis to avoid Bordetella pertussis-induced immunity.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Highlights of the 14th InternationalmSphere · 2025Article
- Pertussis Vaccines Scarcely Provide Protection againstVaccines · 2024Review
- Darwin review: the evolution of virulence in human pathogens.Proceedings. Biological sciences · 2024Review
- Repeat-Unit Elongations To Produce Bacterial Complex Long Polysaccharide Chains, an O-Antigen Perspective.EcoSal Plus · 2023Review
- Article
- Viral and bacterial coinfection of the respiratory tract in a 10-month-old child.BMJ case reports · 2020Article
- Enhancement of immune response against Bordetella spp. by disrupting immunomodulation.Scientific reports · 2019Article
- Immunomodulation as a Novel Strategy for Prevention and Treatment ofFrontiers in immunology · 2019Review
- Bordetella parapertussis outbreak in Southeastern Minnesota and the United States, 2014.Medicine · 2017Observational
- Prior exposure to Bordetella species as an exclusion criterion in the baboon model of pertussis.The Journal of veterinary medical science · 2017Article
- Bordetella parapertussis Circumvents Neutrophil Extracellular Bactericidal Mechanisms.PloS one · 2017Article
- Contribution of pertussis toxin to the pathogenesis of pertussis disease.Pathogens and disease · 2015Review
- Bordetella parapertussis outbreak in Bisham, Pakistan in 2009-2010: fallout of the 9/11 syndrome.Epidemiology and infection · 2015Article
- Bordetella parapertussis survives inside human macrophages in lipid raft-enriched phagosomes.Infection and immunity · 2014Article
- Comparative analyses of a cystic fibrosis isolate of Bordetella bronchiseptica reveal differences in important pathogenic phenotypes.Infection and immunity · 2014Article
- Bordetella parapertussis survives the innate interaction with human neutrophils by impairing bactericidal trafficking inside the cell through a lipid raft-dependent mechanism mediated by the lipopolysaccharide O antigen.Infection and immunity · 2012Article
- Lack of cross-protection against Bordetella holmesii after pertussis vaccination.Emerging infectious diseases · 2012Article
- Decreased leukocyte accumulation and delayed Bordetella pertussis clearance in IL-6-/- mice.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis.Infection and immunity · 2011Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Bordetella pertussis and Bordetella parapertussis are closely related endemic human pathogens which cause whooping cough, a disease that is reemerging in human populations. Despite how closely related these pathogens are, their coexistence and the limited efficacy of B. pertussis vaccines against B. parapertussis suggest a lack of cross-protective immunity between the two. We sought to address the ability of infection-induced immunity against one of these pathogens to protect against subsequent infection by the other using a mouse model of infection. Immunity induced by B. parapertussis infection protected against subsequent infections by either species. However, immunity induced by B. pertussis infection prevented subsequent B. pertussis infections but did not protect against B. parapertussis infections. The O antigen of B. parapertussis inhibited binding of antibodies to the bacterial surface and was required for B. parapertussis to colonize mice convalescent from B. pertussis infection. Thus, the O antigen of B. parapertussis confers asymmetrical cross-immunity between the causative agents of whooping cough. We propose that these findings warrant investigation of the relative role of B. parapertussis in the resurgence of whooping cough.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.