ReviewJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2007
Reflections on the interpretation of heterogeneity and strain differences based on very limited PCR sequence data from Kaposi's sarcoma-associated herpesvirus genomes.
Review in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Case Report: From Kaposi's sarcoma to primary effusive lymphoma.Frontiers in medicine · 2025Article
- Molecular epidemiology of Kaposi sarcoma virus in Spain.PloS one · 2022Article
- Intra-host changes in Kaposi sarcoma-associated herpesvirus genomes in Ugandan adults with Kaposi sarcoma.PLoS pathogens · 2021Article
- Seroprevalence of Kaposi's sarcoma-associated herpesvirus among HIV-infected Uygurs in Xinjiang, China.Journal of medical virology · 2017Article
- Article
- Strain Variation and Disease Severity in Congenital Cytomegalovirus Infection: In Search of a Viral Marker.Infectious disease clinics of North America · 2015Review
- Seroprevalence of Kaposi's sarcoma-associated herpesvirus and risk factors in Xinjiang, China.Journal of medical virology · 2009Article
- Theory of sampling and its application in tissue based diagnosis.Diagnostic pathology · 2009Article
- Evaluation of global clustering patterns and strain variation over an extended ORF26 gene locus from Kaposi's sarcoma herpesvirus.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2007Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Ever since the original identification of fragments of KSHV DNA in Kaposi's sarcoma (KS) tissue by Chang et al. in 1994, PCR has been used successfully and extensively to detect the virus in clinical samples from the accepted etiological diseases of KS, PEL and MCD. However, a number of other clinical and epidemiological studies claiming evidence for KSHV in multiple myeloma or sarcoid and more recently in primary pulmonary hypertension, as well as claims about the biological significance of DNA sequence polymorphisms based just on small ORF26 PCR DNA fragments have not been convincing. Here, we evaluate the validity and interpretations of previous results in the context of both the observed rates and global patterns of sequence variability within an extended ORF26 locus, as well as from the perspective of the overall levels of KSHV variability found after sampling multiple loci across the complete KSHV genome. The results cast doubts on most claims for biological significance for these polymorphisms, which instead correlate with viral subtype clustering arising from geographic and ethnic divergence of the ancestral human hosts. In addition, we describe several observations that help to explain likely sources of the often either unexpectedly high or unexpectedly low levels of sporadic variability seen in the PCR DNA sequence data reported in some of those studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.