ArticleJournal of neuroimmunology2007
Differential ex vivo nitric oxide production by acutely isolated neonatal and adult microglia.
Article in Journal of neuroimmunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Histone deacetylase 3 regulates microglial function through histone deacetylation.Epigenetics · 2023Article
- Biomaterial and Therapeutic Approaches for the Manipulation of Macrophage Phenotype in Peripheral and Central Nerve Repair.Pharmaceutics · 2021Review
- Inhibition of Colony Stimulating Factor 1 Receptor Suppresses Neuroinflammation and Neonatal Hypoxic-Ischemic Brain Injury.Frontiers in neurology · 2021Article
- Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.Scientific reports · 2018Article
- The effects of fisetin on lipopolysaccharide-induced depressive-like behavior in mice.Metabolic brain disease · 2016Article
- Culture and characterization of microglia from the adult murine retina.TheScientificWorldJournal · 2014Article
- Culturing microglia from the neonatal and adult central nervous system.Journal of visualized experiments : JoVE · 2013Article
- hsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brain.Journal of virology · 2013Article
- Spontaneous autoimmunity in the absence of IL-2 is driven by uncontrolled dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Inhibition of TLR ligand- and interferon gamma-induced murine microglial activation by Panax notoginseng.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Article
- Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Major histocompatibility complex haplotype determines hsp70-dependent protection against measles virus neurovirulence.Journal of virology · 2009Article
- Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Microglia are the macrophage population residing in the parenchyma of the central nervous system (CNS), and are thought to play critical roles in CNS development, homeostasis and defense against pathogens. Microglia are capable of rapidly responding to microbial pathogens through engagement of their Toll-like receptors (TLRs). We first compared the efficiency of these responses in primary microglia acutely isolated from adult and neonatal mice. While the cytokine and chemokine responses of adult microglia were generally higher than those of neonatal cells stimulated ex vivo through TLRs, the nitric oxide response of neonatal microglia was markedly enhanced relative to the adult cells. We then went on to identify culture conditions such as exposure to M-SCF or GM-CSF that markedly enhanced the nitric oxide response of microglia, particularly those from the adult CNS. Finally, we demonstrate that the differential nitric oxide response of neonatal and adult microglia is not only limited to the mouse, but also extends to rat microglia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.