ArticleFEBS letters2007
Stimulus interval, rate and direction differentially regulate phosphorylation for mechanotransduction in neonatal cardiac myocytes.
Article in FEBS letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- The Role of Mechanotransduction in Contact Inhibition of Locomotion and Proliferation.International journal of molecular sciences · 2024Review
- Cardiomyocyte external mechanical unloading activates modifications of α-actinin differently from sarcomere-originated unloading.The FEBS journal · 2023Article
- Striated muscle proteins are regulated both by mechanical deformation and by chemical post-translational modification.Biophysical reviews · 2021Review
- Hang on tight: reprogramming the cell with microstructural cues.Biomedical microdevices · 2019Review
- Ventilation-Like Mechanical Strain Modulates the Inflammatory Response of BEAS2B Epithelial Cells.Oxidative medicine and cellular longevity · 2019Article
- Variation in stiffness regulates cardiac myocyte hypertrophy via signaling pathways.Canadian journal of physiology and pharmacology · 2016Article
- Tissue-Engineering for the Study of Cardiac Biomechanics.Journal of biomechanical engineering · 2016Review
- Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes.Stem cell research & therapy · 2014Review
- Focal adhesion signaling in heart failure.Pflugers Archiv : European journal of physiology · 2014Review
- Phosphatidylinositol 4,5-bisphosphate regulates CapZβ1 and actin dynamics in response to mechanical strain.American journal of physiology. Heart and circulatory physiology · 2013Article
- CapZ and actin capping dynamics increase in myocytes after a bout of exercise and abates in hours after stimulation ends.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions.Biochimica et biophysica acta · 2013Review
- The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation.The Annals of thoracic surgery · 2012Article
- Formation, contraction, and mechanotransduction of myofribrils in cardiac development: clues from genetics.Biochemistry research international · 2012Article
- Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction.The Annals of thoracic surgery · 2011Article
- Cyclic stretch induces alveolar epithelial barrier dysfunction via calpain-mediated degradation of p120-catenin.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Micromechanical regulation in cardiac myocytes and fibroblasts: implications for tissue remodeling.Pflugers Archiv : European journal of physiology · 2011Review
- Growth of engineered human myocardium with mechanical loading and vascular coculture.Circulation research · 2011Article
- Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling.The Annals of thoracic surgery · 2011Article
- Hypertrophy, gene expression, and beating of neonatal cardiac myocytes are affected by microdomain heterogeneity in 3D.Biomedical microdevices · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The effect of interval, direction and rate of strain on mechanotransduction in neonatal rat cardiomyocytes is determined for focal adhesion kinase (Y397pFAK), extracellular signal-regulated kinase ERK1/2 (Thr(183)/Tyr(185)) and paxillin (pY31) and phosphorylation time courses to 10% strain assessed. Cells are non-responsive at 5 min but recover at 15 min (P<0.03) with FAK nuclear translocation by 30 min. Cyclic biaxial strain increased phosphorylation from slower to faster rates (P<0.05). Uniaxial strain to groove-aligned myocytes increased FAK and ERK1/2 phosphorylation transversely more than longitudinally (P<0.05). Mechanotransduction may have a refractory period of 5 min and differentiate directions and rates of strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.