ArticleNeuron2007
Fragile X tremor/ataxia syndrome: blame the messenger!
Article in Neuron, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Identification of GOLPH3 Partners inCells · 2021Article
- Nervous translation, do you get the message? A review of mRNPs, mRNA-protein interactions and translational control within cells of the nervous system.Cellular and molecular life sciences : CMLS · 2014Review
- Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons.The Journal of cell biology · 2014Article
- FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The pur protein family: genetic and structural features in development and disease.Journal of cellular physiology · 2013Review
- Translational control at the synapse: role of RNA regulators.Trends in biochemical sciences · 2013Review
- Learning and memory deficits consequent to reduction of the fragile X mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Spatial code recognition in neuronal RNA targeting: role of RNA-hnRNP A2 interactions.The Journal of cell biology · 2011Article
- Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function.Neuron · 2008Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rCGG repeats in premutant alleles of the fragile X gene (FMR1) cause neurodegeneration in Drosophila and are thought to cause fragile X-associated tremor/ataxia syndrome in humans. Two reports in this issue of Neuron (Jin et al. and Sofola et al.) present data indicating a disease mechanism involving disruption of RNA-binding protein function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.