Evidence map›Paper›PMID 17697887›Full record

ReviewMethods in enzymology2007

Methods for identifying novel integrin ligands.

Denise K Marciano, Sumiko Denda, Louis F Reichardt

Open access · greenAbstract readReview
In one paragraph

Review in Methods in enzymology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Denise K MarcianoDepartment of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, California, USA.
Sumiko Denda
Louis F Reichardt
Howard Hughes Medical Institute · USShiseido Group (Japan) · JPUniversity of California, San Francisco · US

Funding

STUDIES ON A NEURTITE OUTGROWTH FACTORR01NS019090 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REICHARDT, LOUIS FRENCH · 1985 to 2009
$3.4M
NINDS NIH HHS R01 NS019090
6 · The paper itself

Abstract

Integrins are cell adhesion receptors that have many important roles in organ development and tissue integrity, functioning to mediate interactions between cells and the ECM. The entire repertoire of integrins is vast, and the specific roles of each are determined by unique integrin-ligand interactions. These interactions allow for dynamic regulation of multiple processes. Despite intense efforts to elucidate individual integrin ligands, existing methods have been limiting. In this chapter, we describe methods developed in our laboratory to identify new integrin ligands that should be useful for characterizing novel integrin functions. These methods are applicable for studies on a variety of integrins, and may be extended to other cell surface receptors as well.

Indexed as

AnimalsHumansIntegrinsLigandsIntegrinsLigands

Identifiers

PMID17697887
PMCPMC2623245
OpenAlexW1608073643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.