ReviewClinical and experimental immunology2007
Translational mini-review series on immunodeficiency: molecular defects in common variable immunodeficiency.
Review in Clinical and experimental immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 86 citations in OpenAlex.
- Antibody Secretion Capacity in CVID Patients: Immunoglobulin Isotypes and Antigen Specificities After T-Cell-Dependent In Vitro Stimulation.Journal of clinical medicine · 2025Article
- Autoimmune cytopenias in inborn errors of immunity: associations with monogenic mutations and immunologic parameters.BMC immunology · 2025Article
- Coexistence of a Leaky SCID Phenotype With Hyperphenylalaninemia in an Adult Case.Case reports in immunology · 2025Article
- B Cell Disorders in Children-Part I.Current allergy and asthma reports · 2020Review
- Idiopathic, Refractory Sweet's Syndrome Associated with Common Variable Immunodeficiency: a Case Report and Literature Review.Current allergy and asthma reports · 2019Review
- New approach to investigate Common Variable Immunodeficiency patients using spectrochemical analysis of blood.Scientific reports · 2019Article
- Evaluating the Genetics of Common Variable Immunodeficiency: Monogenetic Model and Beyond.Frontiers in immunology · 2018Article
- Common variable immunodeficiency associated with microdeletion of chromosome 1q42.1-q42.3 and inositol 1,4,5-trisphosphate kinase B (ITPKB) deficiency.Clinical & translational immunology · 2016Article
- Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease.Gastroenterology · 2015Article
- Rare variants at 16p11.2 are associated with common variable immunodeficiency.The Journal of allergy and clinical immunology · 2015Article
- Genetic defects and the role of helper T-cells in the pathogenesis of common variable immunodeficiency.Advanced biomedical research · 2014Review
- Tolerance and autoimmunity in primary immunodeficiency disease: a comprehensive review.Clinical reviews in allergy & immunology · 2013Review
- CD27+ B cells from a subgroup of common variable immunodeficiency patients are less sensitive to apoptosis rescue regardless of interleukin-21 signalling.Clinical and experimental immunology · 2013Article
- Clinical variability of family members with the C104R mutation in transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI).Journal of clinical immunology · 2013Article
- B lymphocytes as effector cells in the immunotherapy of cancer.Journal of surgical oncology · 2012Review
- B cell responses to CpG correlate with CXCL16 expression levels in common variable immunodeficiency.TheScientificWorldJournal · 2012Article
- Clinical and technical phosphoproteomic research.Proteome science · 2011Article
- Genome-wide association identifies diverse causes of common variable immunodeficiency.The Journal of allergy and clinical immunology · 2011Article
- Defective B-cell response to Toll-like receptor-9 ligands in common variable immunodeficiency.Current allergy and asthma reports · 2010Article
- Immune globulin subcutaneous (human), 20% liquid.P & T : a peer-reviewed journal for formulary management · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Common variable immunodeficiency (CVID) is a primary immunodeficiency that typically affects adults and is characterized by abnormalities of quantative and qualitative humoral function that are heterogeneous in their immunological profile and clinical manifestations. The recent identification of four monogenic defects that result in the CVID phenotype also demonstrates that the genetic basis of CVID is highly variable. Mutations in the genes encoding the tumour necrosis factor (TNF) superfamily receptors transmembrane activator and calcium-modulating ligand interactor (TACI) and B cell activation factor of the TNF family receptor (BAFF-R), CD19 and the co-stimulatory molecule inducible co-stimulator molecule (ICOS) all lead to CVID and illustrate the complex interplay required to co-ordinate an effective humoral immune response. The molecular mechanisms leading to the immune defect are still not understood clearly and particularly in the case of TACI, where a number of heterozygous mutations have been found in affected individuals, the molecular pathogenesis of disease requires further elucidation. Together these defects account for perhaps 10-15% of all cases of CVID and it is highly likely that further genetic defects will be identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.