ArticleWorld journal of gastroenterology2007
Effect of lymph node micrometastases on prognosis of gastric carcinoma.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Carnoy's solution increases the number of examined lymph nodes following gastrectomy for adenocarcinoma: a randomized trial.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Trial
- Nomogram models for predicting lymph node metastasis and prognosis in early gastric cancer 60 or older: a population-based cohort study.Discover oncology · 2025Article
- Impact of Removal of Lymph Nodes on Survival in Stage I-III Gastric Signet-Ring Cell Cancer: The More, the Better?Annals of surgical oncology · 2024Article
- TUMOR MARKERS EXPRESSION LEVELS IN GASTRIC CANCER PATIENT'S PERIPHERAL BLOOD BY RT-PCR ASSESSMENT.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2024Article
- Clinical Application of Indocyanine Green Fluorescence Technology in Laparoscopic Radical Gastrectomy.Frontiers in oncology · 2022Article
- Feasibility of Preserving No. 5 and No. 6 Lymph Nodes in Gastrectomy of Proximal Gastric Adenocarcinoma: A Retrospective Analysis of 395 Patients.Frontiers in oncology · 2022Article
- Aberrant Cytokeratin 20 mRNA Expression in Peripheral Blood and Lymph Nodes Indicates Micrometastasis and Poor Prognosis in Patients With Gastric Carcinoma.Technology in cancer research & treatment · 2019Article
- Article
- Recurrence of a pT2N0cM0 Lower Third Gastric Cancer with No. 6 Lymph Node Micrometastasis after R0 Extended Surgery. Should Adjuvant Therapy be Performed in Conventionally Node-Negative but Micrometastasis-Positive pT2 Gastric Cancer?Journal of gastrointestinal cancer · 2017Article
- Current status and scope of lymph node micrometastasis in gastric cancer.Journal of gastric cancer · 2015Review
- Risk factors associated with splenic hilar lymph node metastasis in patients with advanced gastric cancer in northwest China.International journal of clinical and experimental medicine · 2015Article
- Clinical significance of molecular diagnosis for gastric cancer lymph node micrometastasis.World journal of gastroenterology · 2014Article
- Comparison of five staging systems of lymph node metastasis in the gastric carcinoma.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Lymph node micrometastasis in gastrointestinal tract cancer--a clinical aspect.International journal of clinical oncology · 2013Review
- Article
- Prognostic factors in patients with node-negative gastric cancer: an Indian experience.World journal of surgical oncology · 2011Article
- The clinical importance of micrometastases within the lymphatic system in patients after total gastrectomy.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2011Article
- Impact of the number of dissected lymph nodes on survival for gastric cancer after distal subtotal gastrectomy.Gastroenterology research and practice · 2011Article
- Prognostic factors for patients after curative resection for proximal gastric cancer.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2010Article
- Prognostic impact of metastatic lymph node ratio on gastric cancer after curative distal gastrectomy.World journal of gastroenterology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the relationship between lymph node micrometastases and prognosis of patients with gastric carcinoma and to evaluate the significance of the new assessment of nodal status in determining the pN categories in the 5th edition of the UICC TNM classification.
methodsA total of 850 lymph nodes from 30 patients with gastric carcinoma who underwent gastrectomy with lymphadenectomy were assessed by reverse transcription polymerase chain reaction assay in addition to histologic examination. Cytokeratin-20 gene marker was used in this assay.
resultsRoutine examination by HE staining confirmed metastasis in 233 lymph nodes from 20 patients. All these 233 lymph nodes were cytokeratin-20 positive. Moreover, lymph node micrometastases were detected in an additional 67 lymph nodes in 12 of these 20 patients. Lymph node micrometastases were also detected in 10 lymph nodes from 2 of 10 patients who had no obvious metastases identified by HE staining. Totally, lymph node micrometastases were identified by the reverse transcription polymerase chain reaction assay in 77 (12.5%) lymph nodes from 14 (46.7%) patients with gastric carcinoma. Of 27 patients who underwent curative resection, 7 (25.9%) were up-staged (from IB stage to II stage in 1 patient, from IB stage to IIIA stage in 1 patient, from II stage to IIIA stage in 1 patient, from IIIA stage to IIIB stage in 1 patient, from IIIA stage to IV stage in 1 patient, from IIIB stage to IV stage in 2 patients). In a median follow-up of 32 (range 8-36) mo, Kaplan-Meier survival analysis showed significant improvements in median survival (22.86 +/- 3.17 mo, 95% CI: 16.64-29.08 mo vs 18.00 +/- 7.4 mo, 95% CI: 3.33-32.67 mo) of patients with negative lymph node micrometastases over patients with positive lymph node micrometastases (log-rank, P < 0.05).
conclusionLymph node micrometastases have a significant impact on the current staging system of gastric carcinoma, and are significant risk factors for prognosis of patients with gastric carcinoma.
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