Evidence map›Paper›PMID 17695248›Full record

ReviewImmunologic research2007

Dendritic cells and the immunopathogenesis of systemic lupus erythematosus.

Seetha Monrad, Mariana J Kaplan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation.Mammalian genome : official journal of the International Mammalian Genome Society · 2019
    Article
  2. Article
  3. Review
  4. Metabolic Factors that Contribute to Lupus Pathogenesis.Critical reviews in immunology · 2016
    Review
  5. Article
  6. Article
  7. Article
  8. Lupus nephritis: current update.Arthritis research & therapy · 2011
    Review
  9. Review
  10. Article
  11. Innate pathways to B-cell activation and tolerance.Annals of the New York Academy of Sciences · 2010
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Seetha MonradDivision of Rheumatology, University of Michigan, 5520 MSRBI, Box 0680, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.
Mariana J Kaplan
University of Michigan–Ann Arbor · US

Funding

Vector CoreP30AR048310 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REMMER, HENRIETTE ANNA · 2001 to 2010
$5.9M
Mechanisms of T-cell induced-APC cytotoxicity in lupusK08AR048235 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAPLAN, MARIANA J · 2002 to 2006
$643k
The role of dendritic cell-T cell interactions in the p*R03AR050554 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAPLAN, MARIANA J · 2004 to 2006
$228k
NIAMS NIH HHS AR048235NIAMS NIH HHS AR48310NIAMS NIH HHS AR50554
6 · The paper itself

Abstract

Over the last decade, the role of dendritic cells (DCs) in the immunopathogenesis of systemic lupus erythematosus (SLE) has become apparent. As unique mediators of both tolerance and immunity, aberrant myeloid and plasmacytoid DC function can promote autoimmune responses via a number of mechanisms and proinflammatory pathways. This review provides an overview of DC function, the potential role of DCs in promoting autoimmune responses in SLE, and how other abnormalities in lupus can lead to an enhanced engagement of DCs in immune responses. How medications used to treat SLE and other autoimmune conditions may exert effects on DCs is also explored.

Indexed as

AnimalsAutoimmunityDendritic CellsHumansLupus Erythematosus, Systemic

Identifiers

PMID17695248
OpenAlexW2020410667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.