ArticleDiabetologia2007
Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: heritabilities.
Article in Diabetologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.Aging cell · 2016Pooled it
- Variation in the heritability of body mass index based on diverse twin studies: a systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2013Pooled it
- Age effect on the shared etiology of glycemic traits and serum lipids: evidence from a Chinese twin study.Journal of endocrinological investigation · 2024Article
- Frequency of Consumption of Food Groups and Cardio-Metabolic Risk Factors: A Genetically Informative Twin Study in Sri Lanka.Behavior genetics · 2024Article
- Early-life residential green spaces and traffic exposure in association with young adult body composition: a longitudinal birth cohort study of twins.Environmental health : a global access science source · 2023Article
- Quantile-Dependent Heritability of Glucose, Insulin, Proinsulin, Insulin Resistance, and Glycated Hemoglobin.Lifestyle genomics · 2022Article
- Association of the Combined Effects between Insulin-Like Growth Factor-1 Gene Polymorphisms and Negative Life Events with Major Depressive Disorder among Chinese population in the Context of Oxidative Stress.Oxidative medicine and cellular longevity · 2022Article
- APOE and KLF14 genetic variants are sex-specific for low high-density lipoprotein cholesterol identified by a genome-wide association study.Genetics and molecular biology · 2022Article
- Article
- Age dependent association between remnant cholesterol and cardiovascular disease.Atherosclerosis plus · 2021Article
- Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes.Genome medicine · 2021Article
- Metabolically healthy obesity and metabolically obese normal weight: a review.Journal of physiology and biochemistry · 2021Review
- Genomics of body fat distribution.Journal of genetics · 2021Review
- Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes.Scientific reports · 2020Article
- Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events.Journal of the American College of Cardiology · 2019Article
- MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition.EBioMedicine · 2019Article
- Genetic Architecture of Human Obesity Traits in the Rhesus Macaque.Obesity (Silver Spring, Md.) · 2019Article
- Analysis of serum changes in response to a high fat high cholesterol diet challenge reveals metabolic biomarkers of atherosclerosis.PloS one · 2019Article
- Insulin Resistance in Children.Frontiers in endocrinology · 2019Review
- Genetics of obesity and its measures in India.Journal of genetics · 2018Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
aims/hypothesisWe determined the genetic contribution of 18 anthropometric and metabolic risk factors of type 2 diabetes using a young healthy twin population.
methodsTraits were measured in 240 monozygotic (MZ) and 138 dizygotic (DZ) twin pairs aged 18 to 34 years. Twins were recruited from the Belgian population-based East Flanders Prospective Twin Survey, which is characterised by its accurate zygosity determination and extensive collection of perinatal and placental data, including information on chorionicity. Heritability was estimated using structural equation modelling implemented in the Mx software package.
resultsIntra-pair correlations of the anthropometric and metabolic characteristics did not differ between MZ monochorionic and MZ dichorionic pairs; consequently heritabilities were estimated using the classical twin approach. For body mass, BMI and fat mass, quantitative sex differences were observed; genetic variance explained 84, 85 and 81% of the total variation in men and 74, 75 and 70% in women, respectively. Heritability estimates of the waist-to-hip ratio, sum of four skinfold thicknesses and lean body mass were 70, 74 and 81%, respectively. The heritability estimates of fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance and beta cell function, as well as insulin-like growth factor binding protein-1 levels were 67, 49, 48, 62 and 47%, in that order. Finally, for total cholesterol, LDL-cholesterol, HDL-cholesterol, total cholesterol:HDL-cholesterol ratio, triacylglycerol, NEFA and leptin levels, genetic factors explained 75, 78, 76, 79, 58, 37 and 53% of the total variation, respectively. CONCLUSIONS/
interpretationGenetic factors explain the greater part of the variation in traits related to obesity, glucose intolerance/insulin resistance and dyslipidaemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.