ArticleEukaryotic cell2007
Differential regulation and substrate preferences in two peptide transporters of Saccharomyces cerevisiae.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Identification of translation events that drive nonsense-mediated mRNA decay reveals functional roles for noncoding RNAs.bioRxiv : the preprint server for biology · 2025Article
- Metabolic modulation and multi-species interaction:Frontiers in cellular and infection microbiology · 2025Article
- Unlocking the secrets of peptide transport in wine yeast: insights into oligopeptide transporter functions and nitrogen source preferences.Applied and environmental microbiology · 2023Article
- Yeast Plasma Membrane Fungal Oligopeptide Transporters Display Distinct Substrate Preferences despite Their High Sequence Identity.Journal of fungi (Basel, Switzerland) · 2021Article
- New insights into HcPTR2A and HcPTR2B, two high-affinity peptide transporters from the ectomycorrhizal model fungus Hebeloma cylindrosporum.Mycorrhiza · 2020Article
- Landscape of gene expression variation of natural isolates ofMicrobial genomics · 2020Article
- Diversity of Oligopeptide Transport in Yeast and Its Impact on Adaptation to Winemaking Conditions.Frontiers in genetics · 2020Review
- Halo Assay for Toxic Peptides and Other Compounds in Microorganisms.Bio-protocol · 2016Article
- Uptake Assay for Radiolabeled Peptides in Yeast.Bio-protocol · 2016Article
- Horizontal gene transfer drives adaptive colonization of apple trees by the fungal pathogen Valsa mali.Scientific reports · 2016Article
- Elongator-dependent modification of cytoplasmic tRNALysUUU is required for mitochondrial function under stress conditions.Nucleic acids research · 2015Article
- L-Methionine repressible promoters for tuneable gene expression in Trichoderma reesei.Microbial cell factories · 2015Article
- Evolutionary Advantage Conferred by an Eukaryote-to-Eukaryote Gene Transfer Event in Wine Yeasts.Molecular biology and evolution · 2015Article
- Heat stress-induced Cup9-dependent transcriptional regulation of SIR2.Molecular and cellular biology · 2015Article
- Functional implications and ubiquitin-dependent degradation of the peptide transporter Ptr2 in Saccharomyces cerevisiae.Eukaryotic cell · 2014Article
- Specific analogues uncouple transport, signalling, oligo-ubiquitination and endocytosis in the yeast Gap1 amino acid transceptor.Molecular microbiology · 2014Article
- Article
- A dipeptide transporter from the arbuscular mycorrhizal fungus Rhizophagus irregularis is upregulated in the intraradical phase.Frontiers in plant science · 2014Article
- Roles of different peptide transporters in nutrient acquisition in Candida albicans.Eukaryotic cell · 2013Article
- Analysing the substrate multispecificity of a proton-coupled oligopeptide transporter using a dipeptide library.Nature communications · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dal5p has been shown previously to act as an allantoate/ureidosuccinate permease and to play a role in the utilization of certain dipeptides as a nitrogen source in Saccharomyces cerevisiae. Here, we provide direct evidence that dipeptides are transported by Dal5p, although the affinity of Dal5p for allantoate and ureidosuccinate is higher than that for dipeptides. Allantoate, ureidosuccinate, and to a lesser extent allantoin competed with dipeptide transport by reducing the toxicity of the peptide Ala-Eth and decreasing the accumulation of [(14)C]Gly-Leu. In contrast to the well-studied di/tripeptide transporter Ptr2p, whose substrate specificity is very broad, Dal5p preferred to transport non-N-end rule dipeptides. S. cerevisiae W303 was sensitive to the toxic peptide Ala-Eth (non-N-end rule peptide) but not Leu-Eth (N-end rule peptide). Non-N-end rule dipeptides showed better competition with the uptake of [(14)C]Gly-Leu than N-end rule dipeptides. Similar to the regulation of PTR2, DAL5 expression was influenced by the addition of Leu and by the CUP9 gene. However, DAL5 expression was downregulated in the presence of leucine and the absence of CUP9, whereas PTR2 was upregulated. Toxic dipeptide and uptake assays indicated that either Ptr2p or Dal5p was predominantly used for dipeptide transport in the common laboratory strains S288c and W303, respectively. These studies highlight the complementary activities of two dipeptide transport systems under different regulatory controls in common laboratory yeast strains, suggesting that dipeptide transport pathways evolved to respond to different environmental conditions.
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