ArticleBlood2007
Infection of hematopoietic progenitor cells by HIV-1 subtype C, and its association with anemia in southern Africa.
Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- Qualitative and Quantitative Blood Cell Disorders Among High-Level Antiretroviral Therapy-Experienced Children in Northwest Ethiopia: A Cross-Sectional Study.Health science reports · 2025Article
- Assessing HIV-1 subtype C infection dynamics, therapeutic responses and reservoir distribution using a humanized mouse model.Frontiers in immunology · 2025Article
- Recognition of HIV-1-infected fibrocytes lacking Nef-mediated HLA-B downregulation by HIV-1-specific T cells.Journal of virology · 2024Article
- Prevalence of Cytopenia and its Correlation with Immunosuppression in Naïve HIV-1 Infected Patients Initiating First-Line Antiretroviral Therapy: A Pilot Study.Infection & chemotherapy · 2023Article
- Consequences of HIV infection in the bone marrow niche.Frontiers in immunology · 2023Review
- Article
- Hematopoietic Stem and Progenitor Cells (HSPCs).Methods in molecular biology (Clifton, N.J.) · 2022Article
- HIV-1Biology direct · 2021Article
- Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection.Frontiers in cellular and infection microbiology · 2020Article
- Article
- Quiescence Promotes Latent HIV Infection and Resistance to Reactivation from Latency with Histone Deacetylase Inhibitors.Journal of virology · 2017Article
- Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline.AIDS research and human retroviruses · 2016Observational
- Potential implication of residual viremia in patients on effective antiretroviral therapy.AIDS research and human retroviruses · 2015Review
- Resolution of anaemia in a cohort of HIV-infected patients with a high prevalence and incidence of tuberculosis receiving antiretroviral therapy in South Africa.BMC infectious diseases · 2014Article
- Targeting HIV latency: resting memory T cells, hematopoietic progenitor cells and future directions.Expert review of anti-infective therapy · 2014Review
- Bone marrow abnormalities in HIV infected children, report of three cases and review of the literature.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages.World journal of virology · 2013Review
- Cellular and molecular mechanisms involved in the establishment of HIV-1 latency.Retrovirology · 2013Review
- HIV-1 pathogenesis: the virus.Cold Spring Harbor perspectives in medicine · 2012Article
- Short communication: Colony-forming hematopoietic progenitor cells are not preferentially infected by HIV type 1 subtypes A and D in vivo.AIDS research and human retroviruses · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Reports from southern Africa, an area in which human immunodeficiency virus type 1 (HIV-1) infection is caused almost exclusively by subtype C (HIV-1C), have shown increased rates of anemia in HIV-infected populations compared with similar acquired immunodeficiency syndrome (AIDS) patients in the United States, an area predominantly infected with subtype B (HIV-1B). Recent findings by our group demonstrated a direct association between HIV-1 infection and hematopoietic progenitor cell health in Botswana. Therefore, using a single-colony infection assay and quantitative proviral analysis, we examined whether HIV-1C could infect hematopoietic progenitor cells (HPCs) and whether this phenotype was associated with the higher rates of anemia found in southern Africa. The results show that a significant number of HIV-1C, but not HIV-1B, isolates can infect HPCs in vitro (P < .05). In addition, a portion of HIV-1C-positive Africans had infected progenitor cell populations in vivo, which was associated with higher rates of anemia in these patients (P < .05). This represents a difference in cell tropism between 2 geographically separate and distinct HIV-1 subtypes. The association of this hematotropic phenotype with higher rates of anemia should be considered when examining anti-HIV drug treatment regimens in HIV-1C-predominant areas, such as southern Africa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.