ArticleGenome research2007
Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 88 citations in OpenAlex.
- Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats.Aging cell · 2026Article
- Nrf2 Overexpression in Spontaneously Hypertensive Rats Enhances Adipose Tissue Metabolism through Redox-Mediated Suppression of Mitochondrial Oxidative Phosphorylation.Physiological research · 2025Article
- Multi-tissue metabolomics reveal mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease.Redox biology · 2025Article
- Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome.Communications biology · 2024Article
- Disruption of mitochondria-associated ER membranes impairs insulin sensitivity and thermogenic function of adipocytes.Frontiers in cell and developmental biology · 2022Article
- Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat.Physiological research · 2021Review
- Insulin resistance in diabetes: The promise of using induced pluripotent stem cell technology.World journal of stem cells · 2021Review
- Review
- An evolutionary, or "Mitocentric" perspective on cellular function and disease.Redox biology · 2020Review
- Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic.Toxicological sciences : an official journal of the Society of Toxicology · 2018Review
- Comparative Study for the Association of Mitochondrial Haplogroup F+ and Metabolic Syndrome between Longevity and Control Population in Guangxi Zhuang Autonomous Region, China.The journal of nutrition, health & aging · 2018Article
- Cardioprotective Regimen of Adaptation to Chronic Hypoxia Diversely Alters Myocardial Gene Expression in SHR and SHR-mtFrontiers in endocrinology · 2018Article
- Mitochondrial toxicity of tobacco smoke and air pollution.Toxicology · 2017Review
- Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry.Circulation. Cardiovascular genetics · 2016Article
- Mitochondrial Haplotypes Influence Metabolic Traits in Porcine Transmitochondrial Cybrids.Scientific reports · 2015Article
- Metabolic syndrome and the environmental pollutants from mitochondrial perspectives.Reviews in endocrine & metabolic disorders · 2014Review
- Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans.Journal of molecular biology · 2014Article
- Mito-nuclear co-evolution: the positive and negative sides of functional ancient mutations.Frontiers in genetics · 2014Review
- Cytoplasmic hybrid (cybrid) cell lines as a practical model for mitochondriopathies.Redox biology · 2014Review
- Renal angiotensin II type 1 receptor expression and associated hypertension in rats with minimal SHR nuclear genome.Physiological reports · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 6 institutions in 3 countries.
Funding
Abstract
Recently, the relationship of mitochondrial DNA (mtDNA) variants to metabolic risk factors for diabetes and other common diseases has begun to attract increasing attention. However, progress in this area has been limited because (1) the phenotypic effects of variation in the mitochondrial genome are difficult to isolate owing to confounding variation in the nuclear genome, imprinting phenomena, and environmental factors; and (2) few animal models have been available for directly investigating the effects of mtDNA variants on complex metabolic phenotypes in vivo. Substitution of different mitochondrial genomes on the same nuclear genetic background in conplastic strains provides a way to unambiguously isolate effects of the mitochondrial genome on complex traits. Here we show that conplastic strains of rats with identical nuclear genomes but divergent mitochondrial genomes that encode amino acid differences in proteins of oxidative phosphorylation exhibit differences in major metabolic risk factors for type 2 diabetes. These results (1) provide the first direct evidence linking naturally occurring variation in the mitochondrial genome, independent of variation in the nuclear genome and other confounding factors, to inherited variation in known risk factors for type 2 diabetes; and (2) establish that spontaneous variation in the mitochondrial genome per se can promote systemic metabolic disturbances relevant to the pathogenesis of common diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.