ArticleApplied and environmental microbiology2007
Mixed infections, cryptic diversity, and vector-borne pathogens: evidence from Polygenis fleas and Bartonella species.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 68 citations in OpenAlex.
- Bartonella transmission and gut microbiome dynamics in Ceratophyllus sciurorum fleas and their edible dormouse hosts (Glis glis).Parasites & vectors · 2026Article
- Comparative study onFrontiers in veterinary science · 2025Article
- Epidemiological survey and genetic diversity of Bartonella in fleas collected from rodents in Fujian Province, Southeast China.Parasites & vectors · 2024Article
- The diverse genetic genotypes of Bartonella species circulating in rodents from Inner Mongolia, Northern China.PLoS neglected tropical diseases · 2023Article
- Eco-epidemiological screening of multi-host wild rodent communities in the UK reveals pathogen strains of zoonotic interest.International journal for parasitology. Parasites and wildlife · 2022Article
- Didelphis spp. opossums and their parasites in the Americas: A One Health perspective.Parasitology research · 2021Review
- Biomolecular Investigation ofPathogens (Basel, Switzerland) · 2021Article
- Molecular Detection of Microorganisms Associated with Small Mammals and Their Ectoparasites in Mali.The American journal of tropical medicine and hygiene · 2020Article
- Prophage-Driven Genomic Structural Changes Promote Bartonella Vertical Evolution.Genome biology and evolution · 2018Article
- Global fingerprint of humans on the distribution of Bartonella bacteria in mammals.PLoS neglected tropical diseases · 2018Article
- Genetic Diversity of Bartonella spp. in Wild Mammals and Ectoparasites in Brazilian Pantanal.Microbial ecology · 2018Article
- Carrion's Disease: the Sound of Silence.Clinical microbiology reviews · 2018Review
- Elucidating transmission dynamics and host-parasite-vector relationships for rodent-borne Bartonella spp. in Madagascar.Epidemics · 2017Article
- Prevalence and Phylogenetic Analysis of Bartonella Species of Wild Carnivores and Their Fleas in Northwestern Mexico.EcoHealth · 2017Article
- Association of Bartonella Species with Wild and Synanthropic Rodents in Different Brazilian Biomes.Applied and environmental microbiology · 2016Article
- Bartonella spp. - a chance to establish One Health concepts in veterinary and human medicine.Parasites & vectors · 2016Review
- Bartonella infection in rodents and their flea ectoparasites: an overview.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2015Review
- The effect of ecological and temporal factors on the composition of Bartonella infection in rodents and their fleas.The ISME journal · 2014Article
- Associations between innate immune function and ectoparasites in wild rodent hosts.Parasitology research · 2013Article
- Implications of microfauna-host interactions for trypanosome transmission dynamics in Glossina fuscipes fuscipes in Uganda.Applied and environmental microbiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coinfections within hosts present opportunities for horizontal gene transfer between strains and competitive interactions between genotypes and thus can be a critical element of the lifestyles of pathogens. Bartonella spp. are Alphaproteobacteria that parasitize mammalian erythrocytes and endothelial cells. Their vectors are thought to be various biting arthropods, such as fleas, ticks, mites, and lice, and they are commonly cited as agents of various emerging diseases. Coinfections by different Bartonella strains and species can be common in mammals, but little is known about specificity and coinfections in arthropod vectors. We surveyed the rate of mixed infections of Bartonella in flea vectors (Polygenis gwyni) parasitizing cotton rats (Sigmodon hispidus) in which previous surveys indicated high rates of infection. We found that nearly all fleas (20 of 21) harbored one or more strains of Bartonella, with rates of coinfection approaching 90%. A strain previously identified as common in cotton rats was also common in their fleas. However, another common strain in cotton rats was absent from P. gwyni, while a rare cotton rat strain was quite common in P. gwyni. Surprisingly, some samples were also coinfected with a strain phylogenetically related to Bartonella clarridgeiae, which is typically associated with felids and ruminants. Finally, a locus (pap31) that is characteristically borne on phage in Bartonella was successfully sequenced from most samples. However, sequence diversity in pap31 was novel in the P. gwyni samples, relative to other Bartonella previously typed with pap31, emphasizing the likelihood of large reservoirs of cryptic diversity in natural populations of the pathogen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.