ArticleProceedings of the National Academy of Sciences of the United States of America2007
A pathogenicity island replicon in Staphylococcus aureus replicates as an unstable plasmid.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 74 citations in OpenAlex.
- Article
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- SV40 T-antigen uses a DNA shearing mechanism to initiate origin unwinding.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A phage weaponizes a satellite recombinase to subvert viral restriction.Nucleic acids research · 2022Article
- A phage parasite deploys a nicking nuclease effector to inhibit viral host replication.Nucleic acids research · 2022Article
- Staphylococcal self-loading helicases couple the staircase mechanism with inter domain high flexibility.Nucleic acids research · 2022Article
- Phage-inducible chromosomal islands promote genetic variability by blocking phage reproduction and protecting transductants from phage lysis.PLoS genetics · 2022Article
- RAP44 phage integrase-guided 50K genomic island integration inFrontiers in veterinary science · 2022Article
- A novel DNA primase-helicase pair encoded by SCCeLife · 2020Article
- Genome replication dynamics of a bacteriophage and its satellite reveal strategies for parasitism and viral restriction.Nucleic acids research · 2020Article
- Rebooting Synthetic Phage-Inducible Chromosomal Islands: One Method to Forge Them All.Biodesign research · 2020Article
- Identification of an Integrase That Responsible for Precise Integration and Excision ofFrontiers in microbiology · 2019Article
- Phage-inducible chromosomal islands are ubiquitous within the bacterial universe.The ISME journal · 2018Article
- Lysogenization of Staphylococcus aureus RN450 by phages ϕ11 and ϕ80α leads to the activation of the SigB regulon.Scientific reports · 2018Article
- Staphylococcal pathogenicity islands-movers and shakers in the genomic firmament.Current opinion in microbiology · 2017Review
- Phage-inducible islands in the Gram-positive cocci.The ISME journal · 2017Article
- Convergent evolution of pathogenicity islands in helper cos phage interference.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Replicating methicillin resistance?Nature structural & molecular biology · 2016Article
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4 authors at 2 institutions in 2 countries.
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Abstract
The SaPIs are 14- to 17-kb mobile pathogenicity islands in staphylococci that carry genes for superantigen toxins and other virulence factors and are responsible for the toxic shock syndrome and other superantigen-related diseases. They reside at specific chromosomal sites and are induced by certain bacteriophages to initiate an excision-replication-packaging program, resulting in their incorporation into small infective phage-like particles. These are responsible for very high transfer frequencies that often equal and sometimes exceed the plaque-forming titer of the inducing phage. The ability of the SaPIs to replicate autonomously defines them as individual replicons and, like other prokaryotic replicons, they possess replicon-specific initiation functions. In this paper, we report identification of the SaPI replication origin (ori) and replication initiation protein (Rep), which has helicase as well as initiation activity. The SaPI oris are binding sites for the respective Rep proteins and consist of multiple oligonucleotide repeats in two sets, flanking an AT-rich region that may be the site of initial melting. Plasmids containing the rep-ori complex plus an additional gene, pri, can replicate autonomously in Staphylococcus aureus but are very unstable, probably because of defective segregation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.