ArticleJournal of bacteriology2007
Contribution of the FtsQ transmembrane segment to localization to the cell division site.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The structural integrity of the membrane-embedded bacterial division complex FtsQBL studied with molecular dynamics simulations.Computational and structural biotechnology journal · 2023Article
- Localization, Assembly, and Activation of the Escherichia coli Cell Division Machinery.EcoSal Plus · 2021Review
- The PASTA domains ofMicrobiology (Reading, England) · 2020Article
- A 1 MDa protein complex containing critical components of the Escherichia coli divisome.Scientific reports · 2015Article
- The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity.The Journal of biological chemistry · 2015Article
- Structure of CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis, in lipid bilayers.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex.BMC structural biology · 2011Article
- Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex.Journal of bacteriology · 2010Article
- Central domain of DivIB caps the C-terminal regions of the FtsL/DivIC coiled-coil rod.The Journal of biological chemistry · 2009Article
- Divisome under construction: distinct domains of the small membrane protein FtsB are necessary for interaction with multiple cell division proteins.Journal of bacteriology · 2009Article
- Agrobacterium VirB10 domain requirements for type IV secretion and T pilus biogenesis.Molecular microbiology · 2009Article
- FtsW is a dispensable cell division protein required for Z-ring stabilization during sporulation septation in Streptomyces coelicolor.Journal of bacteriology · 2008Article
- Roles of pneumococcal DivIB in cell division.Journal of bacteriology · 2008Article
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Authors and funding
8 authors.
Funding
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Abstract
The Escherichia coli cell division protein FtsQ is a central component of the divisome. FtsQ is a bitopic membrane protein with a large C-terminal periplasmic domain. In this work we investigated the role of the transmembrane segment (TMS) that anchors FtsQ in the cytoplasmic membrane. A set of TMS mutants was made and analyzed for the ability to complement an ftsQ mutant. Study of the various steps involved in FtsQ biogenesis revealed that one mutant (L29/32R;V38P) failed to functionally insert into the membrane, whereas another mutant (L29/32R) was correctly assembled and interacted with FtsB and FtsL but failed to localize efficiently to the cell division site. Our results indicate that the FtsQ TMS plays a role in FtsQ localization to the division site.
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