ArticleJournal of bacteriology2007
Quorum-sensing regulation of the production of Blp bacteriocins in Streptococcus thermophilus.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 104 citations in OpenAlex.
- A Small-Molecular-Weight Bacteriocin-like Inhibitory Substance (BLIS) UI-11 Produced byVeterinary sciences · 2025Article
- Genomic Analysis of Bacteriocin-Producing Staphylococci: High Prevalence of Lanthipeptides and the Micrococcin P1 Biosynthetic Gene Clusters.Probiotics and antimicrobial proteins · 2025Article
- Integrating Bacteriocins and Biofilm-Degrading Enzymes to EliminateInternational journal of molecular sciences · 2025Article
- Preliminary transcriptomic analyses revealFrontiers in microbiology · 2025Article
- Uncovering the arsenal of class II bacteriocins in salivarius streptococci.Communications biology · 2024Article
- Use of Rgg quorum-sensing machinery to create an innovative recombinant protein expression system inMicrobiology (Reading, England) · 2024Article
- Widespread fungal-bacterial competition for magnesium lowers bacterial susceptibility to polymyxin antibiotics.PLoS biology · 2024Article
- Cue-driven microbial cooperation and communication: evolving quorum sensing with honest signaling.BMC biology · 2024Article
- BlpU is a broad-spectrum bacteriocin inFrontiers in microbiology · 2024Article
- Bacterial defences: mechanisms, evolution and antimicrobial resistance.Nature reviews. Microbiology · 2023Review
- Metagenome-mining indicates an association between bacteriocin presence and strain diversity in the infant gut.BMC genomics · 2023Article
- Thermophilin 13: In Silico Analysis Provides New Insight in Genes Involved in Bacteriocin Production.Microorganisms · 2023Article
- The quorum sensing peptide BlpC regulates the transcription of genes outside its associated gene cluster and impacts the growth ofFrontiers in microbiology · 2023Article
- Article
- Distribution of two-component signal transduction systems BlpRH and ComDE across streptococcal species.Frontiers in microbiology · 2022Review
- Three Distinct Proteases Are Responsible for Overall Cell Surface Proteolysis in Streptococcus thermophilus.Applied and environmental microbiology · 2021Article
- The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics.eLife · 2021Article
- Thermophilin 110 inhibits growth and biofilm formation ofBiotechnology reports (Amsterdam, Netherlands) · 2021Article
- Bacteriocin Production by Beta-Hemolytic Streptococci.Pathogens (Basel, Switzerland) · 2021Review
- Friends or Foes-Microbial Interactions in Nature.Biology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The blp gene cluster identified in the genome sequences of Streptococcus thermophilus (blp(St)) LMG18311, CNRZ1066, and LMD-9 displays all the characteristics of a class II bacteriocin locus. In the present study, we showed that the blp(St) locus is only fully functional in strain LMD-9 and regulates the production of antimicrobial peptides that inhibit strains LMG18311 and CNRZ1066. The blp(St) cluster of LMD-9 contains 23 genes that are transcriptionally organized in six operons: blpABC(St) (peptide transporter genes and pheromone gene); blpRH(St) (two-component regulatory system genes); blpD(St)-orf1, blpU(St)-orf3, and blpE-F(St) (bacteriocin precursors and immunity genes); and blpG-X(St) (unknown function). All the operons, except the regulatory unit blpRH(St), were shown to be coregulated at the transcriptional level by a quorum-sensing mechanism involving the mature S. thermophilus pheromone BlpC* (BlpC*(St)), which was extracellularly detected as two active forms (30 and 19 amino acids). These operons are differentially transcribed depending on growth phase and pheromone concentration. They all contain a motif with two imperfect direct repeats in their mapped promoter regions that could serve as binding sites of the response regulator BlpR(St). Through the construction of deletion mutants, the blp(St) locus of strain LMD-9 was shown to encode all the essential functions associated with bacteriocin production, quorum-sensing regulation, and immunity.
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