ReviewCell2007
A "reductionist" view of cardiomyopathy.
Review in Cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- A nitroreductase responsive probe for early diagnosis of pulmonary fibrosis disease.Redox biology · 2024Article
- Nanomaterials-Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Hydrogen selenide, a vital metabolite of sodium selenite, uncouples the sulfilimine bond and promotes the reversal of liver fibrosis.Science China. Life sciences · 2021Article
- Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart.The Journal of biological chemistry · 2020Article
- Monitoring NAD(P)H by an ultrasensitive fluorescent probe to reveal reductive stress induced by natural antioxidants in HepG2 cells under hypoxia.Chemical science · 2019Article
- HTheranostics · 2019Article
- Ascorbic acid induced HepG2 cells' apoptosisTheranostics · 2019Article
- Feasibility of assessing health state by detecting redox state of human body based on Chinese medicine constitution.Chinese journal of integrative medicine · 2016Review
- Reductive potential - a savior turns stressor in protein aggregation cardiomyopathy.Biochimica et biophysica acta · 2015Review
- Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy.Cardiovascular research · 2013Article
- Imaging ROS signaling in cells and animals.Journal of molecular medicine (Berlin, Germany) · 2013Review
- Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease.American journal of physiology. Heart and circulatory physiology · 2013Review
- Thymosin beta 4 prevents oxidative stress by targeting antioxidant and anti-apoptotic genes in cardiac fibroblasts.PloS one · 2011Article
- NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
- Comment on
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress due to the generation of reactive oxygen species has been implicated in many diseases. Rajasekaran et al. (2007) now make the surprising discovery that its counterpart "reductive stress," caused by an increase in reduced glutathione, contributes to cardiomyopathy triggered by protein aggregation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.