Trial reportInternational journal of cardiology2008
Effect of renin-angiotensin aldosteron system blockers on postoperative atrial fibrillation.
Trial report in International journal of cardiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Association of Preoperative Renin-Angiotensin System Inhibitors With Prevention of Postoperative Atrial Fibrillation and Adverse Events: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- Fish oil and atrial fibrillation after cardiac surgery: a meta-analysis of randomized controlled trials.PloS one · 2013Pooled it
- Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting.BioMed research international · 2017Trial
- Effects of ACEI/ARB or CCB use on atrial fibrillation in hypertensive patients following permanent pacemaker implantation.Frontiers in cardiovascular medicine · 2023Article
- Atrial Fibrillation after Lung Cancer Surgery: Prediction, Prevention and Anticoagulation Management.Cancers · 2021Review
- Incidence, Management, Prevention and Outcome of Post-Operative Atrial Fibrillation in Thoracic Surgical Oncology.Journal of clinical medicine · 2019Review
- Author`s Reply.Anatolian journal of cardiology · 2016Article
- SYNTAX score predicts postoperative atrial fibrillation in patients undergoing on-pump isolated coronary artery bypass grafting surgery.Anatolian journal of cardiology · 2016Article
- Oxidant and Inflammatory Mechanisms and Targeted Therapy in Atrial Fibrillation: An Update.Journal of cardiovascular pharmacology · 2015Review
- Pharmacological strategies for prevention of postoperative atrial fibrillation.Expert review of clinical pharmacology · 2015Review
- Article
- Atrial fibrillation and inflammation.World journal of cardiology · 2010Article
- Preoperative angiotensin-blocking drug therapy is not associated with atrial fibrillation after cardiac surgery.American heart journal · 2010Article
- Post-operative Atrial Fibrillation - Pathophysiology, Treatment and Prevention.Journal of atrial fibrillationReview
- Primary Prevention of Atrial Fibrillation where are we in 2012?Journal of atrial fibrillationReview
- The Role Of Renin Angiotensin System In Atrial Fibrillation.Journal of atrial fibrillationReview
Corrections and comments
- Commented on by
- Commented on byAuthor`s Reply.2016
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNo randomized studies have been conducted to evaluate the effects of renin-angiotensin aldosteron system blockers on postoperative atrial fibrillation (AF). The aim of this study was to evaluate the effect of angiotensin converting-enzyme inhibitors (ACEIs) and ACEI plus candesartan, an angiotensin receptor blocker on postoperative AF.
methodsA group of consecutive patients undergoing coronary artery bypass and/or valve surgery was studied (n=128). The patients were randomized to ACEI group (n=49) and ACEI plus candesartan group (n=49). Thirty patients not on ACEI or angiotensin receptor blocker constituted the control group.
resultsThe rate of postoperative AF was higher in the control group (33.3%) compared to the ACEI group (12.2%, p=0.02) or ACEI plus candesartan group (10.2%, p=0.01). With the Cox proportional model, univariable negative predictors of postoperative AF, were the use of ACEI (RR 0.34, 95% CI 0.12 to 0.93, p=0.03) and the use of ACEI plus candesartan (RR 0.28, 95% CI 0.09 to 0.83, p=0.02); the positive predictor of postoperative AF was age>or=65 (RR 3.10, 95% CI 1.30 to 7.37, p=0.01). With the multivariable Cox proportional model, the only predictor of postoperative AF was age>or=65 (RR 9.70, 95% CI 2.04 to 46.1, p=0.004).
conclusionACEI alone and ACEI plus candesartan decrease the incidence of postoperative AF compared to the control group. Candesartan has no additional effect on the rates of postoperative AF when added to ACEI.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.