ArticleDevelopmental biology2007
A zebrafish LMO4 ortholog limits the size of the forebrain and eyes through negative regulation of six3b and rx3.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Cisplatin-induced hair cell loss in zebrafish neuromasts is accompanied by protein nitration and Lmo4 degradation.Toxicology and applied pharmacology · 2021Article
- A trans-Regulatory Code for the Forebrain Expression of Six3.2 in the Medaka Fish.The Journal of biological chemistry · 2015Article
- EFTUD2 deficiency in vertebrates: Identification of a novel human mutation and generation of a zebrafish model.Birth defects research. Part A, Clinical and molecular teratology · 2015Article
- LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins.Molecular biology reports · 2014Review
- Identification of estrogen target genes during zebrafish embryonic development through transcriptomic analysis.PloS one · 2013Article
- The LIM adaptor protein LMO4 is an essential regulator of neural crest development.Developmental biology · 2012Article
- Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics.Development (Cambridge, England) · 2010Article
- poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis.Developmental biology · 2010Article
- Loss of LMO4 in the retina leads to reduction of GABAergic amacrine cells and functional deficits.PloS one · 2010Article
- Complexity of cis-regulatory organization of six3a during forebrain and eye development in zebrafish.BMC developmental biology · 2010Article
- Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression.Development (Cambridge, England) · 2009Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
The Six3 and Rx3 homeodomain proteins are essential for the specification and proliferation of forebrain and retinal precursor cells of the vertebrate brain, and the regulatory networks that control their expression are beginning to be elucidated. We identify the zebrafish lmo4b gene as a negative regulator of forebrain growth that acts via restriction of six3 and rx3 expression during early segmentation stages. Loss of lmo4b by morpholino knockdown results in enlargement of the presumptive telencephalon and optic vesicles and an expansion of the post-gastrula expression domains of six3 and rx3. Overexpression of lmo4b by mRNA injection causes complementary phenotypes, including a reduction in the amount of anterior neural tissue, especially in the telencephalic, optic and hypothalamic primordia, and a dosage-sensitive reduction in six3 and rx3 expression. We suggest that lmo4b activity is required at the neural boundary to restrict six3b expression, and later within the neural plate to for attenuation of rx3 expression independently of its effect on six3 transcription. We propose that lmo4b has an essential role in forebrain development as a modulator of six3 and rx3 expression, and thus indirectly influences neural cell fate commitment, cell proliferation and tissue growth in the anterior CNS.
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