Evidence map›Paper›PMID 17692745›Full record

ArticleJournal of the American College of Cardiology2007

Measurement of the interleukin family member ST2 in patients with acute dyspnea: results from the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) study.

James L Januzzi, W Frank Peacock, Alan S Maisel, Claudia U Chae, Robert L Jesse, Aaron L Baggish, Michelle O'Donoghue, Rahul Sakhuja, Annabel A Chen, Roland R J van Kimmenade and 3 more

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 208 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05335629 nacompletedstarted 2022, after this paper: background citation

Evaluation of the Effect of Dapagliflozin on Cardiac Remodeling in Post Myocardial Infarction Patients

Ran2022Enrolled54Registered outcomes2Posted comparisons0ConditionsDiabetes Mellitus, Type 2, Myocardial Infarction, Myocardial Remodeling, VentricularArmsDapagliflozin 10mg Tab
PMID 15226248PMID 15110792PMID 29153199PMID 28450225PMID 27521518PMID 26615096PMID 25748771PMID 25464491PMID 2532153PMID 21943940PMID 17492053PMID 16286016other papers from this trial
Open the trial in the graph
NCT01570153 completednot on this mapstarted 2012, after this paper: background citation

Biomarkers Plus Bioimpedance Vector Analysis to Predict Cardiorenal Syndrome Onset and Prognosis in Patients With Acutely Decompensated Heart Failure: Biomonitoring and Cardiorenal Syndrome in Heart Failure(BIONICS-HF) Trial

TypeobservationalSponsorMassachusetts General HospitalRan2012 to 2013Enrolled100ConditionsCardiorenal Syndrome, Acute Decompensated Heart Failure
3 · Its place in the literature

Who cites it

208 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

James L JanuzziDepartment of Medicine and Laboratory Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. JJanuzzi@Partners.org
W Frank Peacock
Alan S Maisel
Claudia U Chae
Robert L Jesse
Aaron L Baggish
Michelle O'Donoghue
Rahul Sakhuja
Annabel A Chen
Roland R J van Kimmenade
Kent B Lewandrowski
Donald M Lloyd-Jones
Alan H B Wu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to examine the value of measurement of the interleukin-1 receptor family member ST2 in patients with dyspnea.

backgroundConcentrations of ST2 have been reported to be elevated in patients with heart failure (HF).

methodsFive hundred ninety-three dyspneic patients with and without acute destabilized HF presenting to an urban emergency department were evaluated with measurements of ST2 concentrations. Independent predictors of death at 1 year were identified.

resultsConcentrations of ST2 were higher among those with acute HF compared with those without (0.50 vs. 0.15 ng/ml; p < 0.001), although amino-terminal pro-brain natriuretic peptide (NT-proBNP) was superior to ST2 for diagnosis of acute HF. Median concentrations of ST2 at presentation to the emergency department were higher among decedents than survivors at 1 year (1.08 vs. 0.18 ng/ml; p < 0.001), and in multivariable analyses, an ST2 concentration > or =0.20 ng/ml strongly predicted death at 1 year in dyspneic patients as a whole (HR = 5.6, 95% confidence interval [CI] 2.2 to 14.2; p < 0.001) as well as those with acute HF (hazard ratio [HR] = 9.3, 95% CI 1.3 to 17.8; p = 0.03). This risk associated with an elevated ST2 in dyspneic patients with and without HF appeared early and was sustained at 1 year after presentation (log-rank p value <0.001). A multi-marker approach with both ST2 and NT-proBNP levels identified subjects with the highest risk for death.

conclusionsAmong dyspneic patients with and without acute HF, ST2 concentrations are strongly predictive of mortality at 1 year and might be useful for prognostication when used alone or together with NT-proBNP.

Indexed as

AgedAged, 80 and overBiomarkersCase-Control StudiesCohort StudiesDyspneaFemaleHeart FailureHumansInterleukin-1 Receptor-Like 1 ProteinMaleMiddle AgedPredictive Value of TestsReceptors, Cell SurfaceSurvival RateBiomarkersIL1RL1 protein, humanInterleukin-1 Receptor-Like 1 ProteinReceptors, Cell Surface

Identifiers

PMID17692745

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.