Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 52 citations in OpenAlex.

1. The effect of selenium therapy in critically ill patients: an umbrella review of systematic reviews and meta-analysis of randomized controlled trials.European journal of medical research · 2023
   Pooled it
2. The Impact on the Clinical Prognosis of Low Serum Selenium Level in Patients with Severe Trauma: Systematic Review and Meta-Analysis.Nutrients · 2022
   Pooled it
3. The clinical outcomes of selenium supplementation on critically ill patients: A meta-analysis of randomized controlled trials.Medicine · 2019
   Pooled it
4. Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI)).German medical science : GMS e-journal · 2010
   Guideline
5. [Prevention, diagnosis, treatment, and follow-up care of sepsis. First revision of the S2k Guidelines of the German Sepsis Society (DSG) and the German Interdisciplinary Association for Intensive and Emergency Care Medicine (DIVI)].Der Anaesthesist · 2010
   Guideline
6. High-dose selenium substitution in sepsis: a prospective randomized clinical trial.Intensive care medicine · 2011
   Trial
7. The impact of selenium administration on severe sepsis or septic shock: a meta-analysis of randomized controlled trials.African health sciences · 2021
   Article
8. Pyroglutamic acidosis by glutathione regeneration blockage in critical patients with septic shock.Critical care (London, England) · 2019
   Article
9. Urosepsis--Etiology, Diagnosis, and Treatment.Deutsches Arzteblatt international · 2015
   Review
10. Selenium effect on oxidative stress factors in septic rats.Advanced pharmaceutical bulletin · 2014
    Article
11. Restoration of antioxidant enzymes in the therapeutic use of selenium in septic patients.Wiener klinische Wochenschrift · 2013
    Observational
12. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities.Antioxidants & redox signaling · 2012
    Review
13. [Immunonutrition after trauma].Der Unfallchirurg · 2011
    Article
14. Improving the Practice of Nutrition Therapy in the NRITLD Critically Ill Patients: An International Quality Improvement Project.Tanaffos · 2011
    Article
15. [Supportive and adjunctive sepsis therapy].Der Internist · 2009
    Review
16. Update on postinjury nutrition.Current opinion in critical care · 2008
    Review

Corrections and comments

• Comment on
  Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study.2007

Authors and funding

1 author at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as