ArticleJournal of the American Chemical Society2007
De novo design of a single-chain diphenylporphyrin metalloprotein.
Article in Journal of the American Chemical Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed.
- Article
- Mapping the energy landscape of PROTAC-mediated protein-protein interactions.Computational and structural biotechnology journal · 2023Article
- De novo protein design of photochemical reaction centers.Nature communications · 2022Article
- Catalysis and Electron Transfer inChemical reviews · 2022Review
- Rational design of photosynthetic reaction center protein maquettes.Frontiers in molecular biosciences · 2022Article
- Allosteric cooperation in a de novo-designed two-domain protein.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Metal-Templated Design of Chemically Switchable Protein Assemblies with High-Affinity Coordination Sites.Angewandte Chemie (International ed. in English) · 2020Article
- Review
- Self-assembly and soluble aggregate behavior of computationally designed coiled-coil peptide bundles.Soft matter · 2018Article
- De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy.Nature chemistry · 2017Article
- Structural-functional analysis of engineered protein-nanoparticle assemblies using graphene microelectrodes.Chemical science · 2017Article
- Thermophilic Ferritin 24mer Assembly and Nanoparticle Encapsulation Modulated by Interdimer Electrostatic Repulsion.Biochemistry · 2017Article
- Improving target amino acid selectivity in a permissive aminoacyl tRNA synthetase through counter-selection.Organic & biomolecular chemistry · 2017Article
- First principles design of a core bioenergetic transmembrane electron-transfer protein.Biochimica et biophysica acta · 2016Article
- Photoinduced Electron Transfer Elicits a Change in the Static Dielectric Constant of a de Novo Designed Protein.Journal of the American Chemical Society · 2016Article
- De Novo Construction of Redox Active Proteins.Methods in enzymology · 2016Article
- Crystal structure of designed PX domain from cytokine-independent survival kinase and implications on evolution-based protein engineering.Journal of structural biology · 2015Article
- Computational de novo design of a four-helix bundle protein--DND_4HB.Protein science : a publication of the Protein Society · 2015Article
- Article
- Metalloproteins containing cytochrome, iron-sulfur, or copper redox centers.Chemical reviews · 2014Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
We describe the computational design of a single-chain four-helix bundle that noncovalently self-assembles with fully synthetic non-natural porphyrin cofactors. With this strategy, both the electronic structure of the cofactor as well as its protein environment may be varied to explore and modulate the functional and photophysical properties of the assembly. Solution characterization (NMR, UV-vis) of the protein showed that it bound with high specificity to the desired cofactors, suggesting that a uniquely structured protein and well-defined site had indeed been created. This provides a genetically expressed single-chain protein scaffold that will allow highly facile, flexible, and asymmetric variations to enable selective incorporation of different cofactors, surface-immobilization, and introduction of spectroscopic probes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.