ArticleWorld journal of urology2007
Protective role of erythropoietin during testicular torsion of the rats.
Article in World journal of urology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Antioxidant Strategies in Testicular Ischemia-Reperfusion Injury-Translational Insights and Clinical Implications for Testicular Torsion Management.Antioxidants (Basel, Switzerland) · 2026Review
- The synergistic activity of fisetin on quercetin improves testicular recover in ischemia-reperfusion injury in rats.Scientific reports · 2025Article
- Comparison of the therapeutic effect of platelet-rich plasma and injectable platelet-rich fibrin on testicular torsion/detorsion injury in rats.Scientific reports · 2024Article
- Erythropoietin Effect on Testicular Germinal Epithelium Cells in Undescended Testis Mice Model.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2021Article
- Testicular Torsion and Spermatogenesis.Advances in experimental medicine and biology · 2021Article
- Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?World journal of methodology · 2017Review
- Erythropoietin and sildenafil protect against ischemia/reperfusion injury following testicular torsion in adult rats.Experimental and therapeutic medicine · 2017Article
- Mechanisms of testicular torsion and potential protective agents.Nature reviews. Urology · 2014Review
- Comparison of erythropoietin and sildenafil protective role against ischemia/reperfusion injury of the testis in adult rats.International urology and nephrology · 2014Article
- The effect of erythropoietin on ischemia/reperfusion injury after testicular torsion/detorsion: a randomized experimental study.ISRN urology · 2013Article
- Melanocortin 4 receptor activation protects against testicular ischemia-reperfusion injury by triggering the cholinergic antiinflammatory pathway.Endocrinology · 2011Article
- Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion.Clinics (Sao Paulo, Brazil) · 2011Article
- Effect of korean red ginseng on testicular tissue injury after torsion and detorsion.Korean journal of urology · 2010Article
- Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury.World journal of urology · 2009Article
- The protective effect of erythropoietin infusion on testicular torsion/detorsion: an experimental study.International urology and nephrology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testicular torsion is an important clinical urgency. Similar mechanisms occurred after detorsion of the affected testis as in the ischemia reperfusion (I/R) damage. This study was designed to investigate the effects of erythropoietin (EPO) treatment after unilateral testicular torsion. Fifty male Sprague-Dawley rats were divided into five groups. Group 1 underwent a sham operation of the right testis under general anesthesia. Group 2 was same as sham, and EPO (3,000 IU/kg) infused i.p., group 3 underwent a similar operation but the right testis was rotated 720 degrees clockwise for 1 h, maintained by fixing the testis to the scrotum, and saline infused during the procedure. Group 4 underwent similar torsion but EPO was infused half an hour before the detorsion procedure, and in group 5, EPO was infused after detorsion procedure. Four hours after detorsion, ipsilateral and contralateral testes were taken out for evaluation. Treatment with EPO improved testicular structures in the ipsilateral testis but improvement was less in the contralateral testis histologically, but EPO treatment decreased germ cell apoptosis in both testes following testicular IR. TNF-alpha, IL-1beta, IL-6 and nitrite levels decreased after EPO treatment especially in the ipsilateral testis. We conclude that testicular I/R causes an increase in germ cell apoptosis both in the ipsilateral and contralateral testes. Erythropoietin has antiapoptotic and anti-inflammatory effects following testicular torsion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.