Trial reportBMJ (Clinical research ed.)2007
Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations.
Trial report in BMJ (Clinical research ed.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 94 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Nonalcoholic Fatty Liver Disease With Probiotics and Prebiotics
A Clinical Study to Determine the Effects of a Novel Probiotic Microbial Composite™ on Improving Digestive Health and Key Growth Parameters in Undernourished Young Children
Who cites it
94 citing papers in PubMed, 8 syntheses or guidelines pooled it, 328 citations in OpenAlex.
- A Comprehensive Review and Meta-analysis on the Treatment of Acute Gastroenteritis in Children with a Bacillus clausii Preparation (EnterogerminaAdvances in therapy · 2025Pooled it
- Probiotics for treating acute infectious diarrhoea.The Cochrane database of systematic reviews · 2020Pooled it
- AGA Technical Review on the Role of Probiotics in the Management of Gastrointestinal Disorders.Gastroenterology · 2020Guideline
- Efficacy ofWorld journal of gastroenterology · 2019Pooled it
- Pooled it
- Gastroenteritis Therapies in Developed Countries: Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Systematic review of probiotics for the treatment of community-acquired acute diarrhea in children.BMC public health · 2013Pooled it
- Probiotics for treating acute infectious diarrhoea.The Cochrane database of systematic reviews · 2010Pooled it
- Efficacy and Safety of the Adjuvant Use of Probiotic Bacillus clausii Strains in Pediatric Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study.Paediatric drugs · 2023Trial
- A Multicenter, Randomized, Double-blind, Placebo-controlled Trial of Saccharomyces boulardii in Infants and Children With Acute Diarrhea.The Pediatric infectious disease journal · 2020Trial
- ProbioticNutrients · 2019Trial
- Effect of maternal supplement beverage with and without probiotics during pregnancy and lactation on maternal and infant health: a randomized controlled trial in the Philippines.BMC pregnancy and childbirth · 2018Trial
- The Role of Probiotics in the Treatment of Dysentery: a Randomized Double-Blind Clinical Trial.Probiotics and antimicrobial proteins · 2017Trial
- Lactobacillus GG for treatment of acute childhood diarrhoea: an open labelled, randomized controlled trial.The Indian journal of medical research · 2014Trial
- The effect of a multispecies synbiotic mixture on the duration of diarrhea and length of hospital stay in children with acute diarrhea in Turkey: single blinded randomized study.European journal of pediatrics · 2013Trial
- Trial
- The effect of Lactobacillus GG on acute diarrheal illness in the pediatric emergency department.Pediatric emergency care · 2012Trial
- Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways.Proceedings of the National Academy of Sciences of the United States of America · 2011Trial
- Probiotics in the treatment of acute rotavirus diarrhoea. A randomized, double-blind, controlled trial using two different probiotic preparations in Bolivian children.BMC infectious diseases · 2010Trial
- Trial
34 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the efficacy of five probiotic preparations recommended to parents in the treatment of acute diarrhoea in children. Design Randomised controlled clinical trial in collaboration with family paediatricians over 12 months.
settingPrimary care.
participantsChildren aged 3-36 months visiting a family paediatrician for acute diarrhoea.
interventionChildren's parents were randomly assigned to receive written instructions to purchase a specific probiotic product: oral rehydration solution (control group); Lactobacillus rhamnosus strain GG; Saccharomyces boulardii; Bacillus clausii; mix of L delbrueckii var bulgaricus, Streptococcus thermophilus, L acidophilus, and Bifidobacterium bifidum; or Enterococcus faecium SF68.
main outcome measuresPrimary outcomes were duration of diarrhoea and daily number and consistency of stools. Secondary outcomes were duration of vomiting and fever and rate of admission to hospital. Safety and tolerance were also recorded.
results571 children were allocated to intervention. Median duration of diarrhoea was significantly shorter (P<0.001) in children who received L rhamnosus strain GG (78.5 hours) and the mix of four bacterial strains (70.0 hours) than in children who received oral rehydration solution alone (115.0 hours). One day after the first probiotic administration, the daily number of stools was significantly lower (P<0.001) in children who received L rhamnosus strain GG and in those who received the probiotic mix than in the other groups. The remaining preparations did not affect primary outcomes. Secondary outcomes were similar in all groups.
conclusionsNot all commercially available probiotic preparations are effective in children with acute diarrhoea. Paediatricians should choose bacterial preparations based on effectiveness data. TRIAL REGISTRATION NUMBER: Current Controlled Trials ISRCTN56067537 [controlled-trials.com].
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.