ArticleProceedings of the National Academy of Sciences of the United States of America2007
The AKAP Yu is required for olfactory long-term memory formation in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling.Nature communications · 2023Article
- The carboxypeptidase D homolog silver regulates memory formation via insulin pathway in Drosophila.Protein & cell · 2016Article
- The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication.The EMBO journal · 2016Article
- A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.British journal of pharmacology · 2014Review
- AKAPS act in a two-step mechanism of memory acquisition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Synapsin function in GABA-ergic interneurons is required for short-term olfactory habituation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The circadian neuropeptide PDF signals preferentially through a specific adenylate cyclase isoform AC3 in M pacemakers of Drosophila.PLoS biology · 2012Article
- Proteomic and transcriptomic analysis of visual long-term memory in Drosophila melanogaster.Protein & cell · 2011Article
- Dopamine reveals neural circuit mechanisms of fly memory.Trends in neurosciences · 2010Review
- How does the royal family of Tudor rule the PIWI-interacting RNA pathway?Genes & development · 2010Review
- Genetic disruptions of Drosophila Pavlovian learning leave extinction learning intact.Genes, brain, and behavior · 2010Article
- Fragile x mental retardation 1 and filamin a interact genetically in Drosophila long-term memory.Frontiers in neural circuits · 2010Article
- Short- and long-term memory in Drosophila require cAMP signaling in distinct neuron types.Current biology : CB · 2009Article
- Review
- Distinctive neuronal networks and biochemical pathways for appetitive and aversive memory in Drosophila larvae.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- ben Functions with scamp during synaptic transmission and long-term memory formation in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Extensive neurogenetic analysis has shown that memory formation depends critically on cAMP-protein kinase A (PKA) signaling. Details of how this pathway is involved in memory formation, however, remain to be fully elucidated. From a large-scale behavioral screen in Drosophila, we identified the yu mutant to be defective in one-day memory after spaced training. The yu mutation disrupts a gene encoding an A-kinase anchoring protein (AKAP). AKAPs comprise a family of proteins, which determine the subcellular localization of PKAs and thereby critically restrict cAMP signaling within a cell. Further behavioral characterizations revealed that long-term memory (LTM) was disrupted specifically in the yu mutant, whereas learning, short-term memory and anesthesia-resistant memory all appeared normal. Another independently isolated mutation of the yu gene failed to complement the LTM defect associated with the yu mutation, and this phenotypic defect could be rescued by induced acute expression of a yu(+) transgene, suggesting that yu functions physiologically during memory formation. AKAP Yu is expressed preferentially in the mushroom body (MB) neuroanatomical structure, and expression of a yu(+) transgene to the MB, but not to other brain regions, is sufficient to rescue the LTM defect of the yu mutant. These observations lead us to conclude that proper localization of PKA by Yu AKAP in MB neurons is required for the formation of LTM.
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