ArticleThe American journal of pathology2007
Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity.Arthritis research & therapy · 2012Trial
- Contribution of long-lived plasma cells to antibody-mediated allograft rejection.Clinical transplantation and research · 2024Review
- Article
- Robust memory humoral immune response to SARS-CoV-2 in the tonsils of adults and children.Frontiers in immunology · 2023Article
- Memory B cells and long-lived plasma cells in AMR.Renal failure · 2022Review
- Multiplexed histology analyses for the phenotypic and spatial characterization of human innate lymphoid cells.Nature communications · 2021Article
- Modeling human adaptive immune responses with tonsil organoids.Nature medicine · 2021Article
- Evidence for the Presence of Long-Lived Plasma Cells in Nasal Polyps.Allergy, asthma & immunology research · 2020Article
- Factors Affecting Early Antibody Secreting Cell Maturation Into Long-Lived Plasma Cells.Frontiers in immunology · 2019Review
- The Maintenance of Memory Plasma Cells.Frontiers in immunology · 2019Review
- Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture.Journal of visualized experiments : JoVE · 2018Article
- Influence of Plasma Cell Niche Factors on the Recruitment and Maintenance of IRF4hi Plasma Cells and Plasmablasts in Vaccinated, Simian Immunodeficiency Virus-Infected Rhesus Macaques with Low and High Viremia.Journal of virology · 2017Article
- Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling.Cell death and differentiation · 2017Article
- Proteasome inhibition with bortezomib depletes plasma cells and specific autoantibody production in primary thymic cell cultures from early-onset myasthenia gravis patients.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Plasma cell formation, secretion, and persistence: the short and the long of it.Critical reviews in immunology · 2014Review
- Deep cervical lymph node hypertrophy: a new paradigm in the understanding of pediatric obstructive sleep apnea.The Laryngoscope · 2013Article
- Long-lived autoreactive plasma cells drive persistent autoimmune inflammation.Nature reviews. Rheumatology · 2011Review
- MicroRNA 125b inhibition of B cell differentiation in germinal centers.International immunology · 2010Article
- Peripheral blood CD27+ IgG+ B cells rapidly proliferate and differentiate into immunoglobulin-secreting cells after exposure to low CD154 interaction.Immunology · 2009Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 5 countries.
Funding
Abstract
Immunoglobulin-secreting cells comprise both short-lived proliferating plasmablasts and long-lived nonproliferating plasma cells. To determine the phenotype and functional activity of Ig-secreting cells in human lymphoid tissue, we used a tonsillar organ culture model. A significant proportion of IgA and IgG secretion was shown to be mediated by long-lived, nonproliferating plasma cells that coexpressed high levels of CD27 and CD38. The presence of such cells was further corroborated by the finding of enhanced expression in the CD19(+) B-cell population of XBP-1, IRF-4, and particularly Blimp-1 genes involved in the differentiation of plasma cells. Intact tissue seemed to be necessary for optimal functional activity of plasma cells. A strong correlation was found between concentrations of interleukin-6 and IgA or IgG, but not IgM, in culture supernatants suggesting a role for interleukin-6 in the survival of long-lived plasma cells. Taken together, the present study demonstrates that human lymphoid tissue harbors a population of nonproliferating plasma cells that are dependent on an intact microenvironment for ongoing Ig secretion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.