ReviewThe Journal of physiology2007
Multiple vesicle recycling pathways in central synapses and their impact on neurotransmission.
Review in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Astrocytic Cholesterol Fine-Tunes the Balance of Different Modes of Synaptic Exo- and Endocytosis.bioRxiv : the preprint server for biology · 2026Article
- Optical Approaches to Dissect the Structure and Dynamics of the Synapse at Nanoscale Resolution.Advances in neurobiology · 2026Review
- Effect of continuous Ia fibre activity suppression on hyperreflexia-related spasticity and maladaptive synaptic connections in the spinal cord after injury.Scientific reports · 2025Article
- Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses.eLife · 2023Article
- Detection of Activation Sequences in Spiking-Bursting Neurons by means of the Recognition of Intraburst Neural Signatures.Scientific reports · 2018Article
- Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets.Pharmacological reviews · 2017Review
- VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3.Frontiers in cellular neuroscience · 2017Article
- Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling.The Journal of clinical investigation · 2015Article
- Botulinum Neurotoxins Can Enter Cultured Neurons Independent of Synaptic Vesicle Recycling.PloS one · 2015Article
- Contributions of Bcl-xL to acute and long term changes in bioenergetics during neuronal plasticity.Biochimica et biophysica acta · 2014Review
- RhoGTPase-binding proteins, the exocyst complex and polarized vesicle trafficking.Small GTPases · 2014Review
- Recovery of vesicular storage and release parameters after high frequency stimulation in rat hippocampus.Cognitive neurodynamics · 2013Article
- A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.Nature cell biology · 2013Article
- Synaptic activity slows vesicular replenishment at excitatory synapses of rat hippocampus.Cognitive neurodynamics · 2013Article
- Analysis of neurotransmitter release mechanisms by photolysis of caged Ca²⁺ in an autaptic neuron culture system.Nature protocols · 2012Article
- VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.Nature neuroscience · 2012Article
- Ca²⁺ influx slows single synaptic vesicle endocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- History-dependent excitability as a single-cell substrate of transient memory for information discrimination.PloS one · 2010Article
- Dynamic modulation of phasic and asynchronous glutamate release in hippocampal synapses.Journal of neurophysiology · 2010Article
- The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1.Current biology : CB · 2009Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Short-term synaptic depression during repetitive activity is a common property of most synapses. Multiple mechanisms contribute to this rapid depression in neurotransmission including a decrease in vesicle fusion probability, inactivation of voltage-gated Ca(2+) channels or use-dependent inhibition of release machinery by presynaptic receptors. In addition, synaptic depression can arise from a rapid reduction in the number of vesicles available for release. This reduction can be countered by two sources. One source is replenishment from a set of reserve vesicles. The second source is the reuse of vesicles that have undergone exocytosis and endocytosis. If the synaptic vesicle reuse is fast enough then it can replenish vesicles during a brief burst of action potentials and play a substantial role in regulating the rate of synaptic depression. In the last 5 years, we have examined the impact of synaptic vesicle reuse on neurotransmission using fluorescence imaging of synaptic vesicle trafficking in combination with electrophysiological detection of short-term synaptic plasticity. These studies have revealed that synaptic vesicle reuse shapes the kinetics of short-term synaptic depression in a frequency-dependent manner. In addition, synaptic vesicle recycling helps maintain the level of neurotransmission at steady state. Moreover, our studies showed that synaptic vesicle reuse is a highly plastic process as it varies widely among synapses and can adapt to changes in chronic activity levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.