ArticleNucleic acids research2007
Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- mTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase.Scientific reports · 2019Article
- Reciprocal regulation of TORC signaling and tRNA modifications by Elongator enforces nutrient-dependent cell fate.Science advances · 2019Article
- Article
- Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.The Journal of experimental medicine · 2015Article
- Article
- Fission yeast Cdk7 controls gene expression through both its CAK and C-terminal domain kinase activities.Molecular and cellular biology · 2015Article
- A coordinated codon-dependent regulation of translation by Elongator.Cell cycle (Georgetown, Tex.) · 2012Article
- Determining proteome-wide expression levels using reverse protein arrays in fission yeast.Nature protocols · 2012Article
- Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.Chemistry & biology · 2012Article
- Translational control of cell division by Elongator.Cell reports · 2012Article
- Integrity of chromatin and replicating DNA in nuclei released from fission yeast by semi-automated grinding in liquid nitrogen.BMC research notes · 2011Article
- Genome-wide mapping of nuclear mitochondrial DNA sequences links DNA replication origins to chromosomal double-strand break formation in Schizosaccharomyces pombe.Genome research · 2010Article
- Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival.Molecular biology of the cell · 2009Article
- Distinct requirement of RNA polymerase II CTD phosphorylations in budding and fission yeast.TranscriptionArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A screen for genes that can ectopically activate a Rad3-dependent checkpoint block over mitosis in fission yeast has identified the DNA replication initiation factor cdc18 (known as CDC6 in other organisms). Either a stabilized form of Cdc18, the Cdc18-T6A phosphorylation mutant, or overexpression of wild type Cdc18, activate the Rad3-dependent S-M checkpoint in the apparent absence of detectable replication structures and gross DNA damage. This cell cycle block relies on the Rad checkpoint pathway and requires Chk1 phosphorylation and activation. Unexpectedly, Cdc18-T6A induces changes in the mobility of Chromosome III, affecting the size of a restriction fragment containing rDNA repeats and producing aberrant nucleolar structures. Recombination events within the rDNA appear to contribute at least in part to the cell cycle delay. We propose that an elevated level of Cdc18 activates the Rad3-dependent checkpoint either directly or indirectly, and additionally causes expansion of the rDNA repeats on Chromosome III.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.